4-Cresol (CAS 106-44-5)
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4-Cresol, known as 4-Methylphenol or p-cresol, is a chemical compound extensively studied in environmental chemistry and microbiology. As a component of lignin degradation, it serves as a model for understanding the breakdown of complex plant materials in ecosystems. Its role in the biodegradation pathways of soil bacteria is particularly significant, with research focusing on the enzymatic processes that convert 4-Cresol into more readily metabolizable compounds. In analytical chemistry, 4-Cresol is often used as a standard for calibrating instruments designed to detect volatile organic compounds (VOCs) in both environmental and industrial settings. Additionally, its presence in the metabolome of various organisms has made it a compound of interest in the field of metabolomics, where its levels can reflect specific physiological states or environmental exposures.
4-Cresol (CAS 106-44-5) References
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- Bioactivation of 4-methylphenol (p-cresol) via cytochrome P450-mediated aromatic oxidation in human liver microsomes. | Yan, Z., et al. 2005. Drug Metab Dispos. 33: 1867-76. PMID: 16174805
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- Genetic and biochemical characterization of a 4-hydroxybenzoate hydroxylase from Corynebacterium glutamicum. | Huang, Y., et al. 2008. Appl Microbiol Biotechnol. 78: 75-83. PMID: 18071645
- Biodegradation of the ultraviolet filter benzophenone-3 under different redox conditions. | Liu, YS., et al. 2012. Environ Toxicol Chem. 31: 289-95. PMID: 22095591
- Genetic characterization of 4-cresol catabolism in Corynebacterium glutamicum. | Li, T., et al. 2014. J Biotechnol. 192 Pt B: 355-65. PMID: 24480572
- Olsenella scatoligenes sp. nov., a 3-methylindole- (skatole) and 4-methylphenol- (p-cresol) producing bacterium isolated from pig faeces. | Li, X., et al. 2015. Int J Syst Evol Microbiol. 65: 1227-1233. PMID: 25634945
- Characterization of a Unique Pathway for 4-Cresol Catabolism Initiated by Phosphorylation in Corynebacterium glutamicum. | Du, L., et al. 2016. J Biol Chem. 291: 6583-94. PMID: 26817843
- Modelling the role of microbial p-cresol in colorectal genotoxicity. | Al Hinai, EA., et al. 2019. Gut Microbes. 10: 398-411. PMID: 30359553
- The Natural Metabolite 4-Cresol Improves Glucose Homeostasis and Enhances β-Cell Function. | Brial, F., et al. 2020. Cell Rep. 30: 2306-2320.e5. PMID: 32075738
- The Autism Spectrum Disorder-Associated Bacterial Metabolite p-Cresol Derails the Neuroimmune Response of Microglial Cells Partially via Reduction of ADAM17 and ADAM10. | Zheng, Y., et al. 2022. Int J Mol Sci. 23: PMID: 36232346
- Studies on the mechanism of hepatotoxicity of 4-methylphenol (p-cresol): effects of deuterium labeling and ring substitution. | Thompson, DC., et al. 1996. Chem Biol Interact. 101: 1-11. PMID: 8665615
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4-Cresol, 1 g | sc-256805 | 1 g | $32.00 |