4-Chlorophenyl isothiocyanate (CAS 2131-55-7)
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4-Chlorophenyl isothiocyanate (4-CPITC) has garnered significant attention in recent years as an organosulfur compound subject to extensive study. This intriguing isothiocyanate is formed through the reaction of chlorine and phenyl isothiocyanate, and it serves as a valuable reagent in the realm of organic synthesis. The scientific community has been particularly interested in exploring the potential applications of 4-Chlorophenyl isothiocyanate in medicinal chemistry and biochemistry. Its antimicrobial properties have been a focus of investigation, and it has been actively employed in the synthesis of drugs and other bioactive compounds. Moreover, this compound has played a role as a probe in probing protein structure and function within the laboratory setting. Despite its considerable potential, the precise mechanism of action of 4-Chlorophenyl isothiocyanate has not been fully elucidated. One prevailing theory suggests that it may act as a nucleophile, targeting electrophilic centers in proteins and other molecules. Additionally, there is evidence suggesting that 4-Chlorophenyl isothiocyanate could function as a catalyst, accelerating specific biochemical reactions.
4-Chlorophenyl isothiocyanate (CAS 2131-55-7) References
- A general and facile one-pot process of isothiocyanates from amines under aqueous conditions. | Sun, N., et al. 2012. Beilstein J Org Chem. 8: 61-70. PMID: 22423272
- Synthesis, anti-angiogenic and DNA cleavage studies of novel N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)piperidine-4-carboxamide derivatives. | Kambappa, V., et al. 2017. Chem Cent J. 11: 122. PMID: 29189954
- Synthesis and Evaluation of New 1,3,4-Thiadiazole Derivatives as Potent Antifungal Agents. | Karaburun, AÇ., et al. 2018. Molecules. 23: PMID: 30501053
- 2,2-Dimethyl-3,4-dihydro-2H-1,4-benzoxazines as isosteres of 2,2-dimethylchromans acting as inhibitors of insulin release and vascular smooth muscle relaxants. | Pirotte, B., et al. 2019. Medchemcomm. 10: 431-438. PMID: 31015906
- Bicyclic Basic Merbarone Analogues as Antiproliferative Agents. | Spallarossa, A., et al. 2021. Molecules. 26: PMID: 33494519
- Pyrazolyl Thioureas and Carbothioamides with an NNSN Motif against MSSA and MRSA. | Delpe-Acharige, A., et al. 2021. ACS Omega. 6: 6088-6099. PMID: 33718700
- Design, Synthesis, and Antimicrobial Activity of Certain New Indole-1,2,4 Triazole Conjugates. | Al-Wabli, RI., et al. 2021. Molecules. 26: PMID: 33920952
- Application of Deep Eutectic Solvents in the Synthesis of Substituted 2-Mercaptoquinazolin-4(3H)-Ones: A Comparison of Selected Green Chemistry Methods. | Komar, M., et al. 2022. Molecules. 27: PMID: 35056873
- New 1,3,4-Thiadiazole Derivatives with Anticancer Activity. | Janowska, S., et al. 2022. Molecules. 27: PMID: 35335177
- Design, synthesis and computational study of new benzofuran hybrids as dual PI3K/VEGFR2 inhibitors targeting cancer. | El-Khouly, OA., et al. 2022. Sci Rep. 12: 17104. PMID: 36224254
- Synthesis and in vitro antibacterial, antifungal, anti-proliferative activities of novel adamantane-containing thiazole compounds. | Warda, ET., et al. 2022. Sci Rep. 12: 21058. PMID: 36474013
- Synthesis of New Bioactive Indolyl-1,2,4-Triazole Hybrids As Dual Inhibitors for EGFR/PARP-1 Targeting Breast and Liver Cancer Cells. | Youssef, MF., et al. 2022. ACS Omega. 7: 45665-45677. PMID: 36530255
- Novel Adamantane-Linked Isothiourea Derivatives as Potential Chemotherapeutic Agents: Synthesis, Structural Insights, and Antimicrobial/Anti-Proliferative Profiles. | Al-Omary, FAM., et al. 2023. ACS Omega. 8: 13465-13477. PMID: 37065023
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4-Chlorophenyl isothiocyanate, 5 g | sc-238823 | 5 g | $68.00 |