Date published: 2026-4-27

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4-Chloro-L-phenylalanine (CAS 14173-39-8)

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Alternate Names:
L-Phe(4-Cl)-OH; p-Chloro-L-phenylalanine; (S)-2-Amino-3-(4-chlorophenyl)propionic acid
CAS Number:
14173-39-8
Molecular Weight:
199.60
Molecular Formula:
C9H10ClNO2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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4-Chloro-L-phenylalanine, also known as para-chloro-L-phenylalanine or p-Cl-Phe, is a chemical compound that belongs to the class of amino acids. It is an analog of the essential amino acid phenylalanine, in which a chlorine atom is substituted at the para position of the phenyl ring. Phenylalanine is one of the 20 standard amino acids that are used by cells to build proteins. It plays a role in protein synthesis and serves as a precursor for several important molecules in the body, including neurotransmitters like dopamine, norepinephrine, and epinephrine.


4-Chloro-L-phenylalanine (CAS 14173-39-8) References

  1. Aminopeptidase fingerprints, an integrated approach for identification of good substrates and optimal inhibitors.  |  Drag, M., et al. 2010. J Biol Chem. 285: 3310-8. PMID: 19948737
  2. Permeation and systemic absorption of R- and S-baclofen across the nasal mucosa.  |  Zhang, H., et al. 2011. J Pharm Sci. 100: 2717-23. PMID: 21283988
  3. Effects of noradrenaline and serotonin depletions on the neuronal activity of globus pallidus and substantia nigra pars reticulata in experimental parkinsonism.  |  Delaville, C., et al. 2012. Neuroscience. 202: 424-33. PMID: 22138505
  4. Structures and Energetics of Protonated Clusters of Methylamine with Phenylalanine Analogs, Characterized by Infrared Multiple Photon Dissociation Spectroscopy and Electronic Structure Calculations.  |  Kleisath, E., et al. 2015. J Phys Chem A. 119: 6689-702. PMID: 25996562
  5. Enhanced serotonin signaling increases intestinal neuroplasticity.  |  Greig, CJ., et al. 2016. J Surg Res. 206: 151-158. PMID: 27916355
  6. Determining the presence of asthma-related molecules and salivary contamination in exhaled breath condensate.  |  Cruickshank-Quinn, C., et al. 2017. Respir Res. 18: 57. PMID: 28403875
  7. Discovery of a Manduca sexta Allatotropin Antagonist from a Manduca sexta Allatotropin Receptor Homology Model.  |  Kai, ZP., et al. 2018. Molecules. 23: PMID: 29614008
  8. Investigation of Behavioral Dysfunctions Induced by Monoamine Depletions in a Mouse Model of Parkinson's Disease.  |  Li, Y., et al. 2018. Front Cell Neurosci. 12: 241. PMID: 30135645
  9. Mass Spectrometry Guided Discovery and Design of Novel Asperphenamate Analogs From Penicillium astrolabium Reveals an Extraordinary NRPS Flexibility.  |  Subko, K., et al. 2020. Front Microbiol. 11: 618730. PMID: 33519780
  10. Biochemical characterization and synthetic application of aromatic L-amino acid decarboxylase from Bacillus atrophaeus.  |  Choi, Y., et al. 2021. Appl Microbiol Biotechnol. 105: 2775-2785. PMID: 33713143
  11. Solution-State Preorganization of Cyclic β-Hairpin Ligands Determines Binding Mechanism and Affinities for MDM2.  |  Ge, Y., et al. 2021. J Chem Inf Model. 61: 2353-2367. PMID: 33905247
  12. Integrated Analysis of Metabolome and Volatile Profiles of Germinated Brown Rice from the Japonica and Indica Subspecies.  |  Zhou, C., et al. 2021. Foods. 10: PMID: 34681497
  13. Mutants of the white ABCG Transporter in Drosophila melanogaster Have Deficient Olfactory Learning and Cholesterol Homeostasis.  |  Myers, JL., et al. 2021. Int J Mol Sci. 22: PMID: 34884779
  14. Fermentative Production of Halogenated Tryptophan Derivatives with Corynebacterium glutamicum Overexpressing Tryptophanase or Decarboxylase Genes.  |  Kerbs, A., et al. 2022. Chembiochem. 23: e202200007. PMID: 35224830
  15. Highly selective synthesis of d-amino acids from readily available l-amino acids by a one-pot biocatalytic stereoinversion cascade.  |  Zhang, D., et al. 2019. RSC Adv. 9: 29927-29935. PMID: 35531513

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

4-Chloro-L-phenylalanine, 1 g

sc-476894
1 g
$49.00

4-Chloro-L-phenylalanine, 5 g

sc-476894A
5 g
$216.00