Molecular structure of 4-Chloro-DL-phenylalanine methyl ester hydrochloride, CAS Number: 14173-40-1
4-Chloro-DL-phenylalanine methyl ester hydrochloride (CAS 14173-40-1)
Alternate Names:
4,4-DIACETOXYSTIBENE
Application:
4-Chloro-DL-phenylalanine methyl ester hydrochloride is a tryptophan hydroxylase inhibitor
CAS Number:
14173-40-1
Purity:
≥99%
Molecular Weight:
250.12
Molecular Formula:
C10H12ClNO2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
4-Chloro-DL-phenylalanine methyl ester hydrochloride (pCPA methyl ester hydrochloride), also known as para-Chlorophenylalanine methyl ester hydrochloride, is a compound that belongs to the class of phenylalanine derivatives. It is a derivative of phenylalanine with a chloro group attached to the para position of the phenyl ring. This compound is often used as a research tool and is known for its ability to inhibit the activity of aromatic L-amino acid decarboxylase (AADC), an enzyme involved in the conversion of L-DOPA to dopamine.
4-Chloro-DL-phenylalanine methyl ester hydrochloride (CAS 14173-40-1) References
- Modulation of the subthalamic nucleus activity by serotonergic agents and fluoxetine administration. | Aristieta, A., et al. 2014. Psychopharmacology (Berl). 231: 1913-24. PMID: 24271033
- Vortioxetine, but not escitalopram or duloxetine, reverses memory impairment induced by central 5-HT depletion in rats: evidence for direct 5-HT receptor modulation. | Jensen, JB., et al. 2014. Eur Neuropsychopharmacol. 24: 148-59. PMID: 24284262
- Vortioxetine restores reversal learning impaired by 5-HT depletion or chronic intermittent cold stress in rats. | Wallace, A., et al. 2014. Int J Neuropsychopharmacol. 17: 1695-706. PMID: 24852131
- Analgesic Effects of Toad Cake and Toad-cake-containing Herbal Drugs: Analgesic effects of toad cake. | Inoue, E., et al. 2014. J Pharmacopuncture. 17: 74-9. PMID: 25780693
- Differential interaction with the serotonin system by S-ketamine, vortioxetine, and fluoxetine in a genetic rat model of depression. | du Jardin, KG., et al. 2016. Psychopharmacology (Berl). 233: 2813-25. PMID: 27236785
- Anxiolytic- and antidepressant-like activities of a methanolic extract of Morinda citrifolia Linn. (noni) fruit in mice: Involvement of benzodiazepine-GABAAergic, serotonergic and adrenergic systems. | Narasingam, M., et al. 2017. Biomed Pharmacother. 96: 944-952. PMID: 29217165
- S-Ketamine Mediates Its Acute and Sustained Antidepressant-Like Activity through a 5-HT1B Receptor Dependent Mechanism in a Genetic Rat Model of Depression. | du Jardin, KG., et al. 2017. Front Pharmacol. 8: 978. PMID: 29379439
- Sedative and hypnotic effects of Vaccinium bracteatum Thunb. through the regulation of serotonegic and GABAA-ergic systems: Involvement of 5-HT1A receptor agonistic activity. | Oh, DR., et al. 2019. Biomed Pharmacother. 109: 2218-2227. PMID: 30551479
- Effects of dopamine and serotonin synthesis inhibitors on the ketamine-, d-amphetamine-, and cocaine-induced locomotor activity of preweanling and adolescent rats: sex differences. | McDougall, SA., et al. 2020. Behav Brain Res. 379: 112302. PMID: 31655095
- MK801-induced locomotor activity in preweanling and adolescent male and female rats: role of the dopamine and serotonin systems. | McDougall, SA., et al. 2020. Psychopharmacology (Berl). 237: 2469-2483. PMID: 32445054
- Transient serotonin depletion at adolescence, but not at early infancy, reduced subsequent anxiety-like behavior and alcohol intake in female mice. | Bellia, F., et al. 2021. Psychopharmacology (Berl). 238: 215-225. PMID: 33011817
- Importance of dopaminergic neurotransmission for the RU 24969-induced locomotor activity of male and female rats during the preweanling period. | McDougall, SA., et al. 2021. Naunyn Schmiedebergs Arch Pharmacol. 394: 903-913. PMID: 33205248
- Serotonin disruption at gestation alters expression of genes associated with serotonin synthesis and reuptake at weaning. | Fabio, MC., et al. 2022. Psychopharmacology (Berl). 239: 3355-3366. PMID: 36063206
- Preferential Modulatory Action of 5-HT2A Receptors on the Dynamic Regulation of Basal Ganglia Circuits. | Guilhemsang, L., et al. 2023. J Neurosci. 43: 56-67. PMID: 36400530
- Effects of various receptor antagonists on the peripheral antinociceptive activity of aqueous extracts of Dicranopteris linearis, Melastoma malabathricum and Bauhinia purpurea leaves in mice | Zakaria, Z. A., Sodri, N. H., Hassan, H., Anuar, K., & Abdullah, F. C. 2012. CELLMED. 2(4): 38-1.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4-Chloro-DL-phenylalanine methyl ester hydrochloride, 1 g | sc-238813 | 1 g | $54.00 | |||
4-Chloro-DL-phenylalanine methyl ester hydrochloride, 5 g | sc-238813A | 5 g | $234.00 |