Molecular structure of 4-Chloro-DL-phenylalanine, CAS Number: 7424-00-2
4-Chloro-DL-phenylalanine (CAS 7424-00-2)
Alternate Names:
Fenclonine; PCPA
Application:
4-Chloro-DL-phenylalanine is an irreversible tryptophan hydroxylase inhibitor
CAS Number:
7424-00-2
Molecular Weight:
199.63
Molecular Formula:
C9H10ClNO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
4-Chloro-DL-phenylalanine is an irreversible tryptophan hydroxylase inhibitor that depletes serotonin in the brain. 4-Chloro-DL-phenylalanine is an artificially produced compound that is derived from the alkaloid fenclonine, naturally occurring in plants of the Erythrina genus. In scientific research, 4-Chloro-DL-phenylalanine has been utilized extensively in laboratory experiments, particularly in vitro studies. These investigations have focused on examining its impact on cell cultures and exploring potential effects on gene expression.
4-Chloro-DL-phenylalanine (CAS 7424-00-2) References
- Anxiolytic effect of serotonin depletion in the novelty-induced hypophagia test. | Bechtholt, AJ., et al. 2007. Psychopharmacology (Berl). 190: 531-40. PMID: 17165096
- Persistent gut motor dysfunction in a murine model of T-cell-induced enteropathy. | Mizutani, T., et al. 2010. Neurogastroenterol Motil. 22: 196-203, e65. PMID: 19735478
- Ex vivo evaluation of the serotonin 1A receptor partial agonist [³H]CUMI-101 in awake rats. | Palner, M., et al. 2011. Synapse. 65: 715-23. PMID: 21108237
- 4-Chloro-DL-phenylalanine protects against monocrotaline‑induced pulmonary vascular remodeling and lung inflammation. | Bai, Y., et al. 2014. Int J Mol Med. 33: 373-82. PMID: 24337018
- Molecular structure, vibrational spectra, NBO, UV and first order hyperpolarizability, analysis of 4-Chloro-dl-phenylalanine by density functional theory. | Govindarasu, K. and Kavitha, E. 2014. Spectrochim Acta A Mol Biomol Spectrosc. 133: 799-810. PMID: 25000567
- The protective effects of PCPA against monocrotaline-induced pulmonary arterial hypertension are mediated through the downregulation of NFAT-1 and NF-κB. | Bai, Y., et al. 2017. Int J Mol Med. 40: 155-163. PMID: 28560440
- PCPA protects against monocrotaline-induced pulmonary arterial remodeling in rats: potential roles of connective tissue growth factor. | Bai, Y., et al. 2017. Oncotarget. 8: 111642-111655. PMID: 29340081
- Effects of Thryptophan Hydroxylase Blockade by P-Chlorophenylalanine on Contextual Memory Reconsolidation after Training of Different Intensity. | Deryabina, IB., et al. 2020. Int J Mol Sci. 21: PMID: 32197439
- Sub-chronic vortioxetine (but not escitalopram) normalizes brain rhythm alterations and memory deficits induced by serotonin depletion in rats. | Riga, MS., et al. 2020. Neuropharmacology. 178: 108238. PMID: 32750446
- Pharmacological Modulation of Serotonin Levels in Zebrafish Larvae: Lessons for Identifying Environmental Neurotoxicants Targeting the Serotonergic System. | Faria, M., et al. 2021. Toxics. 9: PMID: 34070577
- Overproduction of Gastrointestinal 5-HT Promotes Colitis-Associated Colorectal Cancer Progression via Enhancing NLRP3 Inflammasome Activation. | Li, T., et al. 2021. Cancer Immunol Res. 9: 1008-1023. PMID: 34285037
- Pharmacological Modulation of Behaviour, Serotonin and Dopamine Levels in Daphnia magna Exposed to the Monoamine Oxidase Inhibitor Deprenyl. | Bellot, M., et al. 2021. Toxics. 9: PMID: 34437505
- Regular Aerobic Exercise Attenuates Pain and Anxiety in Mice by Restoring Serotonin-Modulated Synaptic Plasticity in the Anterior Cingulate Cortex. | Zhou, YS., et al. 2022. Med Sci Sports Exerc. 54: 566-581. PMID: 34935710
Inhibitor of:
ASMT, and Enzyme.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4-Chloro-DL-phenylalanine, 5 g | sc-397804 | 5 g | $97.00 |