Molecular structure of 4-Chloro-8-methoxyquinoline, CAS Number: 16778-21-5
4-Chloro-8-methoxyquinoline (CAS 16778-21-5)
Application:
4-Chloro-8-methoxyquinoline is a precursor to a CRTh2(DP2) antagonist
CAS Number:
16778-21-5
Purity:
≥95%
Molecular Weight:
193.63
Molecular Formula:
C10H8ClNO
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
4-Chloro-8-methoxyquinoline is a quinoline compound substituted with both a chloro and a methoxy group. This substituted heterocycle is potentially useful as a building block for synthesis, where both the chloro and methoxy groups may serve as functional sites for elaboration. 4-Chloro-8-methoxyquinoline has been reported in the synthesis of other chloromethoxyquinolines towards the synthesis of substituted 4-aminoquinoline antimalarial compounds. 4-Chloro-8-methoxyquinoline has also been described as a starting material in the synthesis of potent CRTh2(DP2) receptor antagonists.
4-Chloro-8-methoxyquinoline (CAS 16778-21-5) References
- Discovery of potent CRTh2 (DP2) receptor antagonists. | Birkinshaw, TN., et al. 2006. Bioorg Med Chem Lett. 16: 4287-90. PMID: 16753296
- Discovery of 4-(4-(2-((5-Hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)(propyl)amino)ethyl)piperazin-1-yl)quinolin-8-ol and its analogues as highly potent dopamine D2/D3 agonists and as iron chelator: in vivo activity indicates potential application in symptomatic and neuroprotective therapy for Parkinson's disease. | Ghosh, B., et al. 2010. J Med Chem. 53: 2114-25. PMID: 20146482
- The synthesis of some chloromethoxyquinolines. | LAUER, WM. and ARNOLD, RT. 1946. J Am Chem Soc. 68: 1268. PMID: 20990971
- Hypoxia-selective antitumor agents. 15. Modification of rate of nitroreduction and extent of lysosomal uptake by polysubstitution of 4-(alkylamino)-5-nitroquinoline bioreductive drugs. | Siim, BG., et al. 1997. J Med Chem. 40: 1381-90. PMID: 9135035
- A new type of 8-quinolinol amebacidal agent | Burckhalter, J. H., & Edgerton, W. H. 1951. Journal of the American Chemical Society. 73(10): 4837-4839.
- Reaction of 4-chloro-8-methoxyquinoline with hydrogen peroxide | Fujita, T., & Price, J. M. 1968. The Journal of Organic Chemistry. 33(7): 3004-3005.
- Laboratory application of a chemical reactor column. Synthesis of perdeuteriotropilidene | Mueller, P., & Rocek, J. 1968. The Journal of Organic Chemistry. 33(7): 3001-3004.
- Synthesis, characterization, pharmacological, molecular modeling and antimicrobial activity evaluation of novel isomer quinoline derivatives | Murugavel, S., Sundramoorthy, S., Subashini, R., & Pavan, P. 2018. Structural Chemistry. 29(6): 1677-1695.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4-Chloro-8-methoxyquinoline, 500 mg | sc-210009 | 500 mg | $160.00 |