Molecular structure of 4-Chloro-3-ethylphenol, CAS Number: 14143-32-9
4-Chloro-3-ethylphenol (CAS 14143-32-9)
Application:
4-Chloro-3-ethylphenol is a ryanodine receptor antagonist that is a commonly used research tool and diagnostic reagent for malignant hyperthermia
CAS Number:
14143-32-9
Molecular Weight:
156.61
Molecular Formula:
C8H9ClO
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
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SDS & Certificate of Analysis
4-Chloro-3-ethylphenol is a chemical compound that functions as a bacteriostatic agent in experimental applications. It exerts its mechanism of action by disrupting the cell membrane of bacteria, leading to the inhibition of their growth and reproduction. 4-Chloro-3-Ethylphenol targets the lipid bilayer of the bacterial cell membrane, causing destabilization and ultimately leading to the bacteriostatic effect. Through its interaction with the cell membrane, 4-Chloro-3-ethylphenol interferes with the normal functioning of cellular processes, thereby preventing the proliferation of bacteria. 4-Chloro-3-Ethylphenol′s mechanism of action at the molecular level involves the disruption of membrane integrity, which is for the survival and growth of bacteria in experimental conditions.
4-Chloro-3-ethylphenol (CAS 14143-32-9) References
- Dynamic imaging of endoplasmic reticulum Ca2+ concentration in insulin-secreting MIN6 Cells using recombinant targeted cameleons: roles of sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA)-2 and ryanodine receptors. | Varadi, A. and Rutter, GA. 2002. Diabetes. 51 Suppl 1: S190-201. PMID: 11815480
- In vitro effects of 4-chloro-3-ethylphenol in skeletal muscle preparations from malignant hyperthermia susceptible and normal swine. | Gerbershagen, MU., et al. 2002. Eur J Anaesthesiol. 19: 135-40. PMID: 11999597
- Cumulative and bolus in vitro contracture testing with 4-chloro-3-ethylphenol in malignant hyperthermia positive and negative human skeletal muscles. | Gerbershagen, MU., et al. 2005. Anesth Analg. 101: 710-714. PMID: 16115979
- Mitochondria are fast Ca2+ sinks in rat extraocular muscles: a novel regulatory influence on contractile function and metabolism. | Andrade, FH., et al. 2005. Invest Ophthalmol Vis Sci. 46: 4541-7. PMID: 16303946
- Inhibition of serine/threonine phosphatase enhances arachidonic acid-induced [Ca2+]i via protein kinase A. | Saino, T. and Watson, EL. 2009. Am J Physiol Cell Physiol. 296: C88-96. PMID: 18987253
- Store-independent pathways for cytosolic STIM1 clustering in the regulation of store-operated Ca(2+) influx. | Zeng, B., et al. 2012. Biochem Pharmacol. 84: 1024-35. PMID: 22842488
- An effective strategy for a whole-cell biosensor based on putative effector interaction site of the regulatory DmpR protein. | Gupta, S., et al. 2012. PLoS One. 7: e43527. PMID: 22937060
- Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design. | Friberg, A., et al. 2013. J Med Chem. 56: 15-30. PMID: 23244564
- The ryanodine receptor agonist 4-chloro-3-ethylphenol blocks ORAI store-operated channels. | Zeng, B., et al. 2014. Br J Pharmacol. 171: 1250-9. PMID: 24670147
- 4-Chloro-3-ethyl-phenol. | Majer, SH. and Tanski, JM. 2014. Acta Crystallogr Sect E Struct Rep Online. 70: o801. PMID: 25161582
- Elucidation of Cellular Mechanisms That Regulate the Sustained Contraction and Relaxation of the Mammalian Iris. | Sghari, S., et al. 2020. Invest Ophthalmol Vis Sci. 61: 5. PMID: 32882011
- Excitation-contraction coupling in mammalian skeletal muscle: Blending old and last-decade research. | Bolaños, P. and Calderón, JC. 2022. Front Physiol. 13: 989796. PMID: 36117698
- Effects of ryanodine receptor agonist 4-chloro-m-cresol on myoplasmic free Ca2+ concentration and force of contraction in mouse skeletal muscle. | Westerblad, H., et al. 1998. Cell Calcium. 24: 105-15. PMID: 9803311
Inhibitor of:
RyR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4-Chloro-3-ethylphenol, 25 g | sc-254644 | 25 g | $35.00 |