Date published: 2025-10-15

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4-Carboxy-L-phenylalanine (CAS 126109-42-0)

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Alternate Names:
L-Phe(4-COOH)-OH
CAS Number:
126109-42-0
Molecular Weight:
209.20
Molecular Formula:
C10H11NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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4-Carboxy-L-phenylalanine is a compound that is utilized in the field of biochemistry and structural biology, particularly in the study of protein-protein interactions and enzyme catalysis. It is an analog of the amino acid L-phenylalanine with an additional carboxylic acid functional group, which can be incorporated into proteins in place of the native amino acid to investigate the role of phenylalanine residues in protein structure and function. Studies involving 4-Carboxy-L-phenylalanine aim to understand how modifications to the side chains of amino acids affect the dynamics, stability, and activity of enzymes and other proteins. This compound is also of interest in the design of novel peptides and proteins with altered chemical properties or enhanced biophysical characteristics. Additionally, 4-Carboxy-L-phenylalanine is used in research to probe the specificity of amino acid transporters and metabolic pathways.


4-Carboxy-L-phenylalanine (CAS 126109-42-0) References

  1. New chromogenic substrates of human neutrophil cathepsin G containing non-natural aromatic amino acid residues in position P(1) selected by combinatorial chemistry methods.  |  Wysocka, M., et al. 2007. Mol Divers. 11: 93-9. PMID: 17653609
  2. The design, synthesis and activity of pentapeptide pp60c-src inhibitors containing L-phosphotyrosine mimics.  |  Lai, JH., et al. 1998. J Pept Res. 51: 271-81. PMID: 9560002

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

4-Carboxy-L-phenylalanine, 1 g

sc-290107
1 g
$383.00

4-Carboxy-L-phenylalanine, 5 g

sc-290107A
5 g
$2040.00