Date published: 2026-5-2

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4-Bromopyrazole (CAS 2075-45-8)

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Application:
4-Bromopyrazole is a starting material employed in a synthesis of 1,4′-bipyrazoles
CAS Number:
2075-45-8
Molecular Weight:
146.97
Molecular Formula:
C3H3BrN2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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4-Bromopyrazole, an organic compound from the pyrazole family, emerges as a fascinating subject of extensive research. Pyrazoles, a group of heterocyclic compounds featuring three carbon atoms and two nitrogen atoms in a five-membered ring, provide a foundation for its classification. The distinctive properties of 4-Bromopyrazole, such as its capacity to form complexes with transition metals and its potential as a ligand in synthetic organic chemistry, have captivated scientific interest. In the realm of scientific research, 4-Bromopyrazole has garnered attention for its versatile applications. Notably, it serves as a valuable biological probe and a catalyst in biochemical reactions. As a biological probe, it aids in the investigation of enzyme activity, protein structure, and the interactions between proteins and small molecules. Furthermore, in biochemical reactions, 4-Bromopyrazole acts as a catalyst, facilitating the synthesis of peptides and engaging in transition metal catalysis. The mechanism of action for 4-Bromopyrazole varies depending on its application. As a biological probe, it selectively binds to target enzymes or proteins, thereby inducing a conformational change within the target molecule. This conformational change serves as a means to study the structure and functionality of the target. In the context of biochemical reactions, 4-Bromopyrazole serves as an activator for substrates, enabling the formation of new chemical bonds.


4-Bromopyrazole (CAS 2075-45-8) References

  1. Palladium(II) complexes of pyrazolated thio/selenoethers: syntheses, structures, single source precursors of Pd4Se and PdSe nano-particles and potential for catalyzing Suzuki-Miyaura coupling.  |  Sharma, KN., et al. 2013. Dalton Trans. 42: 3908-18. PMID: 23329305
  2. Rapid experimental SAD phasing and hot-spot identification with halogenated fragments.  |  Bauman, JD., et al. 2016. IUCrJ. 3: 51-60. PMID: 26870381
  3. Halogen bonding properties of 4-iodopyrazole and 4-bromopyrazole explored by rotational spectroscopy and ab initio calculations.  |  Cooper, GA., et al. 2017. J Chem Phys. 147: 214303. PMID: 29221380
  4. C-H Imidation and Dual C-H Bond Aminobromination of Five-Membered Heterocycles.  |  Sun, K., et al. 2020. J Org Chem. 85: 1001-1008. PMID: 31872767
  5. Mutagenicity study on pyrazole, seven pyrazole derivatives, and two nitroimidazoles with the L-arabinose resistance test of Salmonella typhimurium.  |  Alejandre-Durán, E., et al. 1986. Environ Mutagen. 8: 611-9. PMID: 3525137
  6. Effects of pyrazole, 4-bromopyrazole and 4-methylpyrazole on mitochondrial function.  |  Cederbaum, AI. and Rubin, E. 1974. Biochem Pharmacol. 23: 203-13. PMID: 4360345
  7. Effect of pyrazole, 4-methylpyrazole, 4-bromopyrazole and 4-iodopyrazole on brain noradrenaline levels of mice and rats.  |  MacDonald, E. 1976. Acta Pharmacol Toxicol (Copenh). 39: 513-24. PMID: 990035

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

4-Bromopyrazole, 1 g

sc-254636
1 g
$55.00