Molecular structure of 4-Bromo-3-hydroxybenzoic acid, CAS Number: 14348-38-0
4-Bromo-3-hydroxybenzoic acid (CAS 14348-38-0)
Application:
4-Bromo-3-hydroxybenzoic acid is an inhibitor of HDC and DDC
CAS Number:
14348-38-0
Purity:
98%
Molecular Weight:
217.02
Molecular Formula:
C7H5BrO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
4-Bromo-3-hydroxybenzoic acid is a probable metabolite of Brocresine (NSD 1055). 4-Bromo-3-hydroxybenzoic acid inhibits both rat fetal and rat gastric HDC (L-histidine carboxylase, EC 4.1.1.22) in vitro with an IC50 of about 1 mM for both enzymes. 4-Bromo-3-hydroxybenzoic acid also inhibits DDC (aromatic-L-amino acid decarboxylase, EC 4.1.1.26) from hog kidney and rat gastric mucosa in vitro with an IC50 of about 1 mM for both enzymes.
4-Bromo-3-hydroxybenzoic acid (CAS 14348-38-0) References
- Structure-Based Optimization of Small-Molecule Inhibitors for the β-Catenin/B-Cell Lymphoma 9 Protein-Protein Interaction. | Zhang, M., et al. 2018. J Med Chem. 61: 2989-3007. PMID: 29566337
- Inhibiting Histamine Signaling Ameliorates Vertigo Induced by Sleep Deprivation. | Qian, S., et al. 2019. J Mol Neurosci. 67: 411-417. PMID: 30644035
- Biomarkers of PEGylated Liposomal Doxorubicin-Induced Hypersensitivity Reaction in Breast Cancer Patients Based on Metabolomics. | Zhuang, W., et al. 2022. Front Pharmacol. 13: 827446. PMID: 35529437
- Histamine Signaling Is Essential for Tissue Macrophage Differentiation and Suppression of Bacterial Overgrowth in the Stomach. | Kim, KH., et al. 2023. Cell Mol Gastroenterol Hepatol. 15: 213-236. PMID: 36167263
Inhibitor of:
DDC, and HDC.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4-Bromo-3-hydroxybenzoic acid, 1 g | sc-261801 | 1 g | $122.00 | |||
4-Bromo-3-hydroxybenzoic acid, 5 g | sc-261801A | 5 g | $273.00 |