Date published: 2025-10-5

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4-Borono-L-phenylalanine (CAS 76410-58-7)

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Alternate Names:
4-Dihydroxyboryl-L-phenylalanine; L-BPA
Application:
4-Borono-L-phenylalanine is a tyrosine analogue
CAS Number:
76410-58-7
Purity:
≥95%
Molecular Weight:
209.01
Molecular Formula:
C9H12BNO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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4-Borono-L-phenylalanine is frequently utilized in research focused on its application in material synthesis and biological studies. As a boron-containing analog of the amino acid phenylalanine, it is of interest in the synthesis of peptides and polymers where the boron moiety imparts unique characteristics to these materials, such as altered thermal stability or reactivity. This compound also serves as useful in the study of amino acid transport and metabolism, providing insights into the uptake and incorporation of modified amino acids into proteins. Additionally, 4-Borono-L-phenylalanine is used in the field of bioconjugation, where it can be attached to various biomolecules to investigate the role of boron in biological systems. In chemical research, it is instrumental in the study of boron chemistry and the development of boron-based compounds with potential applications in materials science and catalysis. Researchers also employ 4-Borono-L-phenylalanine to explore the selective binding of boron-containing molecules to biological targets.


4-Borono-L-phenylalanine (CAS 76410-58-7) References

  1. Synthesis and Initial Biological Evaluation of Boron-Containing Prostate-Specific Membrane Antigen Ligands for Treatment of Prostate Cancer Using Boron Neutron Capture Therapy.  |  Wang, S., et al. 2019. Mol Pharm. 16: 3831-3841. PMID: 31381351
  2. Thermal Sensitive Liposomes Improve Delivery of Boronated Agents for Boron Neutron Capture Therapy.  |  Luderer, MJ., et al. 2019. Pharm Res. 36: 144. PMID: 31392417
  3. DNA Condensation with a Boron-Containing Cationic Peptide for Modeling Boron Neutron Capture Therapy.  |  Perry, CC., et al. 2020. Radiat Phys Chem Oxf Engl 1993. 166: PMID: 32454570
  4. In Vitro Studies to Define the Cell-Surface and Intracellular Targets of Polyarginine-Conjugated Sodium Borocaptate as a Potential Delivery Agent for Boron Neutron Capture Therapy.  |  Fujimura, A., et al. 2020. Cells. 9: PMID: 32977522
  5. Synthesis, Molecular Docking, and In Vitro Boron Neutron Capture Therapy Assay of Carboranyl Sinomenine.  |  Cai, J., et al. 2020. Molecules. 25: PMID: 33066470
  6. A Boron Delivery Antibody (BDA) with Boronated Specific Residues: New Perspectives in Boron Neutron Capture Therapy from an In Silico Investigation.  |  Rondina, A., et al. 2021. Cells. 10: PMID: 34831449
  7. Interactions of Urea-Based Inhibitors with Prostate-Specific Membrane Antigen for Boron Neutron Capture Therapy.  |  Hu, Q., et al. 2021. ACS Omega. 6: 33354-33369. PMID: 34926886
  8. Boron Delivery to Brain Cells via Cerebrospinal Fluid (CSF) Circulation for BNCT in a Rat Melanoma Model.  |  Kusaka, S., et al. 2022. Biology (Basel). 11: PMID: 35336771
  9. Evaluation of 3-Borono-l-Phenylalanine as a Water-Soluble Boron Neutron Capture Therapy Agent.  |  Kondo, N., et al. 2022. Pharmaceutics. 14: PMID: 35631692
  10. Borylated 2,3,4,5-Tetrachlorophthalimide and Their 2,3,4,5-Tetrachlorobenzamide Analogues: Synthesis, Their Glycosidase Inhibition and Anticancer Properties in View to Boron Neutron Capture Therapy.  |  Campkin, DM., et al. 2022. Molecules. 27: PMID: 35684388
  11. A Red-Emitting Fluorescence Sensor for Detecting Boronic Acid-Containing Agents in Cells.  |  Kondo, N., et al. 2022. Sensors (Basel). 22: PMID: 36236770
  12. Boron Delivery to Brain Cells via Cerebrospinal Fluid (CSF) Circulation in BNCT of Brain-Tumor-Model Rats-Ex Vivo Imaging of BPA Using MALDI Mass Spectrometry Imaging.  |  Kusaka, S., et al. 2022. Life (Basel). 12: PMID: 36362940
  13. Exploration of the threshold SUV for diagnosis of malignancy using 18F-FBPA PET/CT.  |  Isohashi, K., et al. 2022. Eur J Hybrid Imaging. 6: 35. PMID: 36464732
  14. Advantages of FBPA PET in evaluating early response of anti-PD-1 immunotherapy in B16F10 melanoma-bearing mice: Comparison to FDG PET.  |  Tatsumi, M., et al. 2022. Front Oncol. 12: 1026608. PMID: 36620558

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

4-Borono-L-phenylalanine, 250 mg

sc-252127
250 mg
$296.00