Date published: 2026-3-4

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4-Aminopyridine-3-methanol (CAS 138116-34-4)

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Alternate Names:
4-Amino-3-hydroxymethylpyridine
CAS Number:
138116-34-4
Purity:
≥95%
Molecular Weight:
124.14
Molecular Formula:
C6H8N2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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4-Aminopyridine-3-methanol, also known as (4-Aminopyridin-3-yl)methanol, is a versatile compound extensively utilized in scientific research. Its applications span a wide range, including studies on enzyme activity, utilization as a substrate for biocatalytic reactions, and synthesis of various compounds. Moreover, 4-Aminopyridine-3-methanol finds utility in investigations pertaining to protein structure and function, serving as a model system for examining the impact of small molecules on biological processes. The proposed mechanism of action suggests that 4-Aminopyridine-3-methanol binds to proteins and enzymes, leading to alterations in their structure and function. Furthermore, it can function as a substrate for biocatalytic reactions, facilitating the exploration of small molecule effects on biological processes.


4-Aminopyridine-3-methanol (CAS 138116-34-4) References

  1. Potassium channel blocker, 4-aminopyridine-3-methanol, restores axonal conduction in spinal cord of an animal model of multiple sclerosis.  |  Leung, G., et al. 2011. Exp Neurol. 227: 232-5. PMID: 21093437
  2. Potassium channel blockers as an effective treatment to restore impulse conduction in injured axons.  |  Shi, R. and Sun, W. 2011. Neurosci Bull. 27: 36-44. PMID: 21270902
  3. The inhibition by di(2-ethylhexyl)-phthalate of erg-mediated K⁺ current in pituitary tumor (GH₃) cells.  |  Wu, SN., et al. 2012. Arch Toxicol. 86: 713-23. PMID: 22314968
  4. Structural studies of five novel bile acid-4-aminopyridine conjugates.  |  Ahonen, KV., et al. 2012. Steroids. 77: 1141-51. PMID: 22813632
  5. Molecular mechanisms of acrolein-mediated myelin destruction in CNS trauma and disease.  |  Shi, R., et al. 2015. Free Radic Res. 49: 888-95. PMID: 25879847
  6. Acrolein-mediated conduction loss is partially restored by K⁺ channel blockers.  |  Yan, R., et al. 2016. J Neurophysiol. 115: 701-10. PMID: 26581866
  7. Potassium channel blockers restore axonal conduction in CNS trauma and diseases.  |  Page, JC. and Shi, R. 2016. Neural Regen Res. 11: 1226-7. PMID: 27651761
  8. A Sensitized IGF1 Treatment Restores Corticospinal Axon-Dependent Functions.  |  Liu, Y., et al. 2017. Neuron. 95: 817-833.e4. PMID: 28817801
  9. Parallel Evaluation of Two Potassium Channel Blockers in Restoring Conduction in Mechanical Spinal Cord Injury in Rat.  |  Page, JC., et al. 2018. J Neurotrauma. 35: 1057-1068. PMID: 29228863
  10. Effectiveness of 4-Aminopyridine for the Management of Spasticity in Spinal Cord Injury: A Systematic Review.  |  Wiener, J., et al. 2018. Top Spinal Cord Inj Rehabil. 24: 353-362. PMID: 30459498
  11. Myelin degeneration induced by mutant superoxide dismutase 1 accumulation promotes amyotrophic lateral sclerosis.  |  Kim, S., et al. 2019. Glia. 67: 1910-1921. PMID: 31290185
  12. Chemogenetic stimulation of proprioceptors remodels lumbar interneuron excitability and promotes motor recovery after SCI.  |  Gao, Z., et al. 2021. Mol Ther. 29: 2483-2498. PMID: 33895324
  13. Evidence for Inhibitory Perturbations on the Amplitude, Gating, and Hysteresis of A-Type Potassium Current, Produced by Lacosamide, a Functionalized Amino Acid with Anticonvulsant Properties.  |  Cho, HY., et al. 2022. Int J Mol Sci. 23: PMID: 35163091

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

4-Aminopyridine-3-methanol, 1 g

sc-267247
1 g
$413.00