Date published: 2025-10-17

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4-Aminophenol (CAS 123-30-8)

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Alternate Names:
4-Hydroxyaniline
CAS Number:
123-30-8
Purity:
≥98%
Molecular Weight:
109.13
Molecular Formula:
C6H7NO
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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4-Aminophenol, a nephrotoxic metabolite of Acetaminophen and Phenacetin, also serves as a N-formylating agent in the catalyst-free N-formylations of amines under standard conditions. In analytical chemistry, this amine acts as a benchmark for measuring redox potential. When it interacts with p-nitrophenyl phosphate, a pink substance is produced the vibrancy of this hue indicates the oxidation potential. Additionally, 4-Aminophenol plays a role in bacterial toxicity research. The compound curtails bacterial proliferation by interfering with the redox process, potentially causing ATP shortages and subsequent cellular death.


4-Aminophenol (CAS 123-30-8) References

  1. Isolation and characterization of a pseudomonas strain that degrades 4-acetamidophenol and 4-aminophenol.  |  Ahmed, S., et al. 2001. Biodegradation. 12: 303-9. PMID: 11995823
  2. Nephrotoxicity of 4-aminophenol glutathione conjugate.  |  Fowler, LM., et al. 1991. Hum Exp Toxicol. 10: 451-9. PMID: 1687859
  3. Biogenic gold nanoparticles for reduction of 4-nitrophenol to 4-aminophenol: an eco-friendly bioremediation.  |  Nabikhan, A., et al. 2018. IET Nanobiotechnol. 12: 479-483. PMID: 29768233
  4. A sensitive sensor based on MOFs derived nanoporous carbons for electrochemical detection of 4-aminophenol.  |  Chen, S., et al. 2020. Ecotoxicol Environ Saf. 191: 110194. PMID: 31951903
  5. Rapid synthesis of a hybrid of rGO/AuNPs/MWCNTs for sensitive sensing of 4-aminophenol and acetaminophen simultaneously.  |  Dou, N. and Qu, J. 2021. Anal Bioanal Chem. 413: 813-820. PMID: 32783127
  6. Validation of the 4-aminophenol color test for the differentiation of marijuana-type and hemp-type cannabis.  |  Lewis, K., et al. 2021. J Forensic Sci. 66: 285-294. PMID: 32956496
  7. Ultrasensitive simultaneous voltammetric determination of 4-aminophenol and acetaminophen based on bimetallic MOF-derived nitrogen-doped carbon coated CoNi alloy.  |  Niu, X., et al. 2021. Anal Chim Acta. 1145: 37-45. PMID: 33453879
  8. Salt-template preparation of Mo5N6 nanosheets with peroxidase- and catalase-like activities and application for colorimetric determination of 4-aminophenol.  |  Xia, C., et al. 2021. Mikrochim Acta. 189: 1. PMID: 34855022
  9. Solvent-assisted cavitation for enhanced removal of organic pollutants - Degradation of 4-aminophenol.  |  Patil, PB. and Bhandari, VM. 2022. J Environ Manage. 311: 114857. PMID: 35278922
  10. The identification of byproducts from the catalytic reduction reaction of 4-nitrophenol to 4-aminophenol: A systematic spectroscopic study.  |  Reddy Bogireddy, NK., et al. 2022. J Environ Manage. 316: 115292. PMID: 35658257
  11. Screen-printed graphite electrode modified with Co3O4nanoparticles and 2D graphitic carbon nitride as an effective electrochemical sensor for 4-aminophenol detection.  |  Jahani, PM., et al. 2022. Nanotechnology. 33: PMID: 35688102
  12. CeO2/Ni-MOF with Synergistic Function of Enrichment and Activation: Efficient Reduction of 4-Nitrophenol Pollutant to 4-Aminophenol.  |  Zhao, H., et al. 2022. Inorg Chem. 61: 19806-19816. PMID: 36417551
  13. Comparative Study of 4-Aminophenol Removal from Aqueous Solutions by Emulsion Liquid Membranes Using Acid and Basic Type 1 Facilitations: Optimisation and Kinetics.  |  León, G., et al. 2022. Membranes (Basel). 12: PMID: 36557120
  14. A carbon based-screen-printed electrode amplified with two-dimensional reduced graphene/Fe3O4 nanocomposite as electroanalytical sensor for monitoring 4-aminophenol in environmental fluids.  |  Wang, M. and Feng, L. 2023. Chemosphere. 323: 138238. PMID: 36868416
  15. 2-Aminophenol and 4-aminophenol toxicity in renal slices from Sprague-Dawley and Fischer 344 rats.  |  Valentovic, MA. and Ball, JG. 1998. J Toxicol Environ Health A. 55: 225-40. PMID: 9772105

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

4-Aminophenol, 250 g

sc-238771
250 g
$32.00

4-Aminophenol, 1 kg

sc-238771A
1 kg
$86.00