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4-Aminoantipyrine (CAS 83-07-8)

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Alternate Names:
4-AA; 4-Aminophenazone; Ampyrone
Application:
4-Aminoantipyrine is a reagent for glucose determination in the presence of peroxidase and phenol
CAS Number:
83-07-8
Purity:
≥97%
Molecular Weight:
203.24
Molecular Formula:
C11H13N3O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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4-Aminoantipyrine is a reagent for glucose determination in the presence of peroxidase and phenol. 4-Aminoantipyrine is thought to operate as an inhibitor of cytochrome P450 enzymes, exerting regulatory influence over their enzymatic activities. Research has revealed its capacity to hinder the metabolism of specific drugs like phenytoin and theophylline, effectively modulating their processing within the body. Moreover, its inhibitory role extends to encompass the metabolism of additional drugs, including warfarin, phenobarbital, and diazepam.


4-Aminoantipyrine (CAS 83-07-8) References

  1. Synthesis and biological activities of 4-aminoantipyrine derivatives derived from betti-type reaction.  |  Mohanram, I. and Meshram, J. 2014. ISRN Org Chem. 2014: 639392. PMID: 24955256
  2. A structural study of 4-aminoantipyrine and six of its Schiff base derivatives.  |  Mnguni, MJ. and Lemmerer, A. 2015. Acta Crystallogr C Struct Chem. 71: 103-9. PMID: 25652276
  3. A first continuous 4-aminoantipyrine (4-AAP)-based screening system for directed esterase evolution.  |  Lülsdorf, N., et al. 2015. Appl Microbiol Biotechnol. 99: 5237-46. PMID: 25947243
  4. Degradation of 4-aminoantipyrine by electro-oxidation with a boron-doped diamond anode: Optimization by central composite design, oxidation products and toxicity.  |  de Melo da Silva, L., et al. 2018. Sci Total Environ. 631-632: 1079-1088. PMID: 29727934
  5. N-demethylation of N-methyl-4-aminoantipyrine, the main metabolite of metamizole.  |  Bachmann, F., et al. 2018. Eur J Pharm Sci. 120: 172-180. PMID: 29746911
  6. Mutagenicity of 4-aminoantipyrine and 4-nitrosoantipyrine, the C-nitroso derivative of antipyrine.  |  Parisis, DM. and Rao, GS. 1988. Mutat Res. 206: 317-26. PMID: 3059178
  7. Computational Analysis of Dipyrone Metabolite 4-Aminoantipyrine As A Cannabinoid Receptor 1 Agonist.  |  Russo, S. and de Azevedo, WF. 2020. Curr Med Chem. 27: 4741-4749. PMID: 31490743
  8. 4-aminoantipyrine modified carbon dots and their analytical applications through response surface methodology.  |  Yan, F., et al. 2020. Spectrochim Acta A Mol Biomol Spectrosc. 227: 117543. PMID: 31685428
  9. Synthesis and Biological Evaluation of 4-Aminoantipyrine Analogues.  |  Ren, H., et al. 2022. Med Chem. 18: 26-35. PMID: 33155926
  10. Cu2+-modified MOF as laccase-mimicking material for colorimetric determination and discrimination of phenolic compounds with 4-aminoantipyrine.  |  Hu, CY., et al. 2021. Mikrochim Acta. 188: 272. PMID: 34302224
  11. Double-signal quantification of amoxicillin based on interaction with 4-aminoantipyrine at copper and nitrogen co-doped carbon quantum dots as an artificial nanozyme.  |  Mahmoud, AM., et al. 2022. Mikrochim Acta. 189: 183. PMID: 35394214
  12. Novel Schiff base scaffolds derived from 4-aminoantipyrine and 2-hydroxy-3-methoxy-5-(phenyldiazenyl)benzaldehyde: Synthesis, antibacterial, antioxidant and anti-inflammatory.  |  Kasare, MS., et al. 2022. J Mol Recognit. 35: e2976. PMID: 35569113
  13. Pharmacokinetic profiles of the two major active metabolites of metamizole, 4-methylaminoantipyrine (MAA) and 4-aminoantipyrine (AA), after intravenous injection in cats.  |  de Paula, VV., et al. 2023. Res Vet Sci. 155: 156-160. PMID: 36701839

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

4-Aminoantipyrine, 10 g

sc-206824
10 g
$37.00

4-Aminoantipyrine, 25 g

sc-206824A
25 g
$39.00

4-Aminoantipyrine, 100 g

sc-206824B
100 g
$66.00