Molecular structure of 4-Amino-TEMPO, free radical, CAS Number: 14691-88-4
4-Amino-TEMPO, free radical (CAS 14691-88-4)
Alternate Names:
4-Amino-2,2,6,6-tetramethylpiperidine-1-oxyl, free rad Tempamine
Application:
4-Amino-TEMPO, free radical is a radical species used as a spin label
CAS Number:
14691-88-4
Purity:
≥97%
Molecular Weight:
171.26
Molecular Formula:
C9H19N2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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4-Amino-TEMPO, free radical, or 4-amino-2,2,6,6-tetramethyl-piperidinyloxyl, is a radical species used as a spin label probe for cellular study. 4-Amino-TEMPO, free radical is derivitized onto more complex molecular structures, particularly selected to provide target specificity to the probe. Once the 4-Amino-TEMPO, free radical-containing molecule has reached its target, electron paramagnetic resonance spectroscopy can be used to gather information about the environment in which the radical electron has been approximated. An ATP analog derivitized with 4-Amino-TEMPO, free radical is described to bind to actin filaments, generating rotational information of the binding cleft, and providing distinct spectral signatures for different conformations of the filament structure encountered by the bound probe.
4-Amino-TEMPO, free radical (CAS 14691-88-4) References
- Synthesis of novel profluorescent nitroxides as dual luminescent-paramagnetic active probes† | Anca G. Coman,a Codruta C. Paraschivescu,a Anca Paun,a Andreea Diac,b Niculina D. Hădade, ORCID logo b Laurent Jouffret,c Arnaud Gautier,*c Mihaela Matache ORCID logo *a and Petre Ionita ORCID logo *ad. New J. Chem.,. 2017,41,: 7472-7480.
- Development of molecular probes for second-site screening and design of protein tyrosine phosphatase inhibitors. | Vazquez, J., et al. 2007. J Med Chem. 50: 2137-43. PMID: 17394300
- Fast-scan voltammetry of cyclic nitroxide free radicals. | Baur, JE., et al. 1996. Anal Chem. 68: 3815-21. PMID: 21619257
- Tuning Spin-Spin Interactions in Radical Dendrimers. | Lloveras, V., et al. 2018. Chemphyschem.. PMID: 29744989
- Rational Functionalization Towards Redox-Active TEMPO Stable Free-Radical-Hydrochar Composites. | Patrinoiu, G., et al. 2021. ChemSusChem. 14: 2042-2049. PMID: 33734591
- Fluorescence Quenching of Humic Substances and Natural Organic Matter by Nitroxide Free Radicals. | Li, H. and McKay, G. 2023. Environ Sci Technol. 57: 719-729. PMID: 36547376
- Mobility and orientation of spin probes attached to nucleotides incorporated into actin. | Naber, N. and Cooke, R. 1994. Biochemistry. 33: 3855-61. PMID: 8142388
- Polarization-enhanced NMR spectroscopy of biomolecules in frozen solution. | Hall, DA., et al. 1997. Science. 276: 930-2. PMID: 9139651
- Chemical Doping of Epitaxial Graphene by Organic Free Radicals | Junghun Choi†, Hangil Lee*‡, Ki-jeong Kim§, Bongsoo Kim§, and Sehun Kim*†. 2010,. J. Phys. Chem. Lett. 1, 2,: 505–509.
- Radical Dendrimers: A Family of Five Generations of Phosphorus Dendrimers Functionalized with TEMPO Radicals | Elena Badetti†∥, Vega Lloveras†∥, Jose Luis Muñoz-Gómez†∥, Rosa Marı́a Sebastián⊥, Anne Marie Caminade§, Jean Pierre Majoral§, Jaume Veciana†∥, and José Vidal-Gancedo*†∥. 2014,. Macromolecules. 47, 22:, 7717–7724.
- Covalently grafted TEMPO on graphene oxide: A composite material for selective oxidations of alcohols | AJ Shakir, DC Culita, J Calderon-Moreno, A Musuc… - Carbon, 2016 - Elsevier. August 2016,. Carbon. Volume 105,: Pages 607-614.
- Novel P,P-diphenylphosphinic amide-TEMPO radicals family: Synthesis, crystal structures, spectroscopic characterization, magnetic properties and DFT calculations | SG Reis, MA del Aguila-Sanchez, GP Guedes… - Polyhedron, 2018 - Elsevier. 1 April 2018,. Polyhedron. Volume 144,: Pages 166-175.
- A strategy to design quaternized poly(2,6-dimethyl-1,4-phenylene oxide) anion exchange membranes by atom transfer radical coupling | X Chu, S Miao, A Zhou, S Liu, L Liu, N Li - Journal of Membrane Science, 2022 - Elsevier. 5 May 2022,. Journal of Membrane Science. Volume 649,: 120397.
Inhibitor of:
Filamin 2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4-Amino-TEMPO, free radical, 100 mg | sc-202018 | 100 mg | $20.00 | |||
4-Amino-TEMPO, free radical, 500 mg | sc-202018A | 500 mg | $33.00 | |||
4-Amino-TEMPO, free radical, 1 g | sc-202018B | 1 g | $156.00 | |||
4-Amino-TEMPO, free radical, 5 g | sc-202018C | 5 g | $312.00 |