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4-Amino-phenylalanine (CAS 943-80-6)

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Alternate Names:
(S)-2-amino-3-(4-aminophenyl)propanoic acid
Application:
4-Amino-phenylalanine is an analog of L-Phenylalanine
CAS Number:
943-80-6
Molecular Weight:
180.20
Molecular Formula:
C9H12N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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4-Amino-phenylalanine is a compound utilized in various biochemical and chemical research areas. It is often used as a building block in the field of peptide synthesis, where it can introduce modifications that help in studying protein-protein interactions and protein structure-function relationships. In the realm of biochemistry, it assists in probing the specificity of enzymes involved in post-translational modifications of proteins, such as kinases and transferases. Moreover, 4-Amino-phenylalanine serves as a tool in the design of novel biopolymers and materials due to its ability to incorporate additional functional groups, which can impart unique physical and chemical properties. Its fluorescent properties, when derivatized, make it a candidate for use in labeling studies to visualize biological molecules in complex systems. The compound is also a subject of interest in the development of new methods for chiral synthesis, given its asymmetric center at the α-carbon.


4-Amino-phenylalanine (CAS 943-80-6) References

  1. N-Tetrahydrofuroyl-(L)-phenylalanine derivatives as potent VLA-4 antagonists.  |  Yang, GX., et al. 2002. Bioorg Med Chem Lett. 12: 1497-500. PMID: 12031328
  2. Structure and function analysis of peptide antagonists of melanoma inhibitor of apoptosis (ML-IAP).  |  Franklin, MC., et al. 2003. Biochemistry. 42: 8223-31. PMID: 12846571
  3. A new route to fullerene substituted phenylalanine derivatives.  |  Yang, J. and Barron, AR. 2004. Chem Commun (Camb). 2884-5. PMID: 15599455
  4. Chemoenzymatic approach to enantiopure streptogramin B variants: characterization of stereoselective pristinamycin I cyclase from Streptomyces pristinaespiralis.  |  Mahlert, C., et al. 2005. J Am Chem Soc. 127: 9571-80. PMID: 15984884
  5. Fullerene-derivatized amino acids: synthesis, characterization, antioxidant properties, and solid-phase peptide synthesis.  |  Yang, J., et al. 2007. Chemistry. 13: 2530-45. PMID: 17236230
  6. Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines.  |  Vullo, D., et al. 2007. Bioorg Med Chem Lett. 17: 4107-12. PMID: 17540561
  7. Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.  |  Vullo, D., et al. 2008. Bioorg Med Chem Lett. 18: 4303-7. PMID: 18627905
  8. Fluorescence lifetime assays: current advances and applications in drug discovery.  |  Pritz, S., et al. 2011. Expert Opin Drug Discov. 6: 663-70. PMID: 22646154
  9. Combinatorial Synthesis, Screening, and Binding Studies of Highly Functionalized Polyamino-amido Oligomers for Binding to Folded RNA.  |  Pokorski, JK. and Appella, DH. 2012. J Nucleic Acids. 2012: 971581. PMID: 22957210
  10. Unnatural amino acid mutagenesis-based enzyme engineering.  |  Ravikumar, Y., et al. 2015. Trends Biotechnol. 33: 462-70. PMID: 26088007
  11. Incorporating unnatural amino acids to engineer biocatalysts for industrial bioprocess applications.  |  Ravikumar, Y., et al. 2015. Biotechnol J. 10: 1862-76. PMID: 26399851
  12. Metabolic engineering of Bacillus subtilis for production of para-aminobenzoic acid - unexpected importance of carbon source is an advantage for space application.  |  Averesch, NJH. and Rothschild, LJ. 2019. Microb Biotechnol. 12: 703-714. PMID: 30980511
  13. Biological activities of photoaffinity labeling analogues of kinins and their irreversible effects on kinin receptors.  |  Escher, E., et al. 1981. J Med Chem. 24: 1409-13. PMID: 6118437
  14. To the problem of biologically active conformation of enkephalin.  |  Siemion, IZ., et al. 1981. Mol Cell Biochem. 34: 23-9. PMID: 7231396

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

4-Amino-phenylalanine, 5 g

sc-299377
5 g
$153.00

4-Amino-phenylalanine, 50 g

sc-299377A
50 g
$454.00

Hi I want to extract 4-Amino-phenylalanine from the reaction mixture after resting cell reaction. do you know which organic component could be helpful? Thanks

Asked by: bmn20
Thank you for your inquiry and your interest in this product. We have not tested 4-Amino-phenylalanine (CAS 943-80-6) in the application you described. We cannot recommend a specific organic component for this purpose. Please contact our European Support Office in Germany directly for any further questions you may have. You can reach us by phone at: +49 6221 4503 0, by email at: europe@scbt.com or by live chat directly on our website, www.scbt.com We are happy to assist you.
Answered by: Technical Support Europe
Date published: 2018-01-31
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Rated 5 out of 5 by from Vullo D; et alVullo D; et al. (PuMed ID: 18627905) determined that 4-Amino-phenylalanine increased human carbonic anhydrase IV the most. -SCBT Publication Review
Date published: 2015-02-23
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4-Amino-phenylalanine is rated 5.0 out of 5 by 1.
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