Molecular structure of 4-Amino-7-chloroquinoline, CAS Number: 1198-40-9
4-Amino-7-chloroquinoline (CAS 1198-40-9)
CAS Number:
1198-40-9
Molecular Weight:
178.62
Molecular Formula:
C9H7ClN2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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4-Amino-7-chloroquinoline, also referred to as 4-ACQ, is an aromatic quinoline compound that has garnered significant interest in various scientific fields. It presents as a colorless solid with a melting point of 296-297°C and a boiling point of 441°C. The scientific community has extensively explored the potential applications of 4-ACQ across various scientific fields. It has been employed in organic synthesis, serving as a fundamental component in the creation of biologically active compounds. In multiple studies, 4-ACQ has demonstrated interactions with nitric oxide (NO) in diverse ways.
4-Amino-7-chloroquinoline (CAS 1198-40-9) References
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- A refined pharmacophore identifies potent 4-amino-7-chloroquinoline-based inhibitors of the botulinum neurotoxin serotype A metalloprotease. | Burnett, JC., et al. 2007. J Med Chem. 50: 2127-36. PMID: 17417831
- Synthesis of 4-aminoquinoline analogues and their platinum(II) complexes as new antileishmanial and antitubercular agents. | Carmo, AM., et al. 2011. Biomed Pharmacother. 65: 204-9. PMID: 21602021
- Cinnamic acid/chloroquinoline conjugates as potent agents against chloroquine-resistant Plasmodium falciparum. | Pérez, B., et al. 2012. ChemMedChem. 7: 1537-40. PMID: 22753234
- In vitro phenotypic screening of 7-chloro-4-amino(oxy)quinoline derivatives as putative anti-Trypanosoma cruzi agents. | Fonseca-Berzal, C., et al. 2014. Bioorg Med Chem Lett. 24: 1209-13. PMID: 24461296
- 4-amino-7-chloroquinoline derivatives for treating Parkinson's disease: implications for drug discovery. | Kim, CH., et al. 2016. Expert Opin Drug Discov. 11: 337-41. PMID: 26924734
- Targeting Asexual and Sexual Blood Stages of the Human Malaria Parasite P. falciparum with 7-Chloroquinoline-Based 1,2,3-Triazoles. | Wadi, I., et al. 2019. ChemMedChem. 14: 484-493. PMID: 30609264
- Comparison of the biological effects in rat of high doses of two 4-amino-7-chloroquinoline derivatives: chloroquine and glafenine. | Dechezleprêtre, S., et al. 1975. Arch Toxicol. 34: 309-14. PMID: 3153
- Synthesis and antimalarial activity of 7-chloroquinoline-tethered sulfonamides and their [1,2,3]-triazole hybrids. | Batra, N., et al. 2022. Future Med Chem. 14: 1725-1739. PMID: 36453182
- Favorable Preclinical Pharmacological Profile of a Novel Antimalarial Pyrrolizidinylmethyl Derivative of 4-amino-7-chloroquinoline with Potent In Vitro and In Vivo Activities. | Basilico, N., et al. 2023. Biomolecules. 13: PMID: 37238706
- Biochemical properties of anti-inflammatory drugs. VI. The effects of chloroquine (resochin), mepacrine (quinacrine) and some of their potential metabolites on cartilage metabolism and oxidative phosphorylation. | Whitehouse, MW. and Boström, H. 1965. Biochem Pharmacol. 14: 1173-84. PMID: 4221789
- Studies of the metabolism of some compounds of the 4-amino-7-chloroquinoline series. | McChesney, EW., et al. 1966. J Pharmacol Exp Ther. 151: 482-93. PMID: 4957157
- N-[7-Chloro-4-[4-(phenoxymethyl)-1H-1,2,3-triazol-1-yl]quinoline]-acetamide | by Paolo Coghi, et al. 2021,. Molbank. 2021(2),: M1213.
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GRB2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4-Amino-7-chloroquinoline, 250 mg | sc-289850 | 250 mg | $61.00 | |||
4-Amino-7-chloroquinoline, 500 mg | sc-289850A | 500 mg | $245.00 |