4-Amino-2,6-dibromopyridine (CAS 39771-34-1)
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4-Amino-2,6-dibromopyridine is a versatile compound widely employed in scientific research. It plays a role in the synthesis of various biologically active substances, particularly inhibitors targeting dihydrofolate reductase, an important enzyme. Additionally, it serves as a ligand in the creation of metal complexes, which find applications in catalysis, drug delivery, and other scientific investigations. Notably, 4-Amino-2,6-dibromopyridine acts as an inhibitor of dihydrofolate reductase (DHFR), an enzyme for folate biosynthesis—a vital nutrient for many organisms. By binding to DHFR, it obstructs its ability to catalyze the conversion of dihydrofolate to tetrahydrofolate. This inhibition disrupts folate biosynthesis, consequently impeding cell growth.
4-Amino-2,6-dibromopyridine (CAS 39771-34-1) References
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- Excited state tuning of bis(tridentate) ruthenium(II) polypyridine chromophores by push-pull effects and bite angle optimization: a comprehensive experimental and theoretical study. | Breivogel, A., et al. 2013. Chemistry. 19: 13745-60. PMID: 24000040
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4-Amino-2,6-dibromopyridine, 1 g | sc-470340 | 1 g | $159.00 |