Date published: 2026-7-7

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4-Amino-1H-pyrazole (CAS 28466-26-4)

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Alternate Names:
4-Aminopyrazole
CAS Number:
28466-26-4
Molecular Weight:
83.09
Molecular Formula:
C3H5N3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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4-Amino-1H-pyrazole , also known as Pyrazolamine, is a colorless solid belonging to the class of pyrazoles—five-membered heterocyclic compounds containing three nitrogen atoms. With its distinct odor and solubility in water, Pyrazolamine finds diverse applications in scientific research. It serves as a precursor for synthesizing other compounds like pyrazolamides and pyrazolones, as well as an enzyme inhibitor and a modulator of biochemical and physiological processes. In scientific research, 1H-Pyrazol-4-amine has been utilized extensively. It acts as a precursor for synthesizing various compounds while also functioning as an inhibitor of enzymes such as acetylcholinesterase. Furthermore, it has been employed as a biochemical and physiological modulator, enabling studies on the effects of drugs on the central nervous system and the impact of different hormones on the body. Its modulatory effects encompass inhibiting the enzyme acetylcholinesterase, responsible for acetylcholine breakdown, and binding to diverse receptors, including opioid receptors, where it can act as an agonist or antagonist.


4-Amino-1H-pyrazole (CAS 28466-26-4) References

  1. Design, Synthesis, and Antitumor Evaluation of 4-Amino-(1H)-pyrazole Derivatives as JAKs Inhibitors.  |  Liang, X., et al. 2016. ACS Med Chem Lett. 7: 950-955. PMID: 27774135
  2. Discovery of a Phosphoinositide 3-Kinase (PI3K) β/δ Inhibitor for the Treatment of Phosphatase and Tensin Homolog (PTEN) Deficient Tumors: Building PI3Kβ Potency in a PI3Kδ-Selective Template by Targeting Nonconserved Asp856.  |  Perreault, S., et al. 2017. J Med Chem. 60: 1555-1567. PMID: 28106991
  3. Synthesis and structure activity relationships of a series of 4-amino-1H-pyrazoles as covalent inhibitors of CDK14.  |  Ferguson, FM., et al. 2019. Bioorg Med Chem Lett. 29: 1985-1993. PMID: 31175010
  4. Novel strategies for synthesizing energetic materials based on BTO with improved performances.  |  Zhang, J., et al. 2019. Dalton Trans. 48: 11848-11854. PMID: 31305841
  5. From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects.  |  Pont, C., et al. 2021. Eur J Med Chem. 225: 113779. PMID: 34418785
  6. Cu(II) bifunctional (N,O,O′) coordination polymer: A case study for complex ab-initio crystal structure determination from PXRD data  |  Valentina Colombo a, Alessandro Cimino b, Angelo Maspero b c, Stefano Tollari b c, Giovanni Palmisano b c, Angelo Sironi a. 2017. Valentina Colombo a, Alessandro Cimino b, Angelo Maspero b c, Stefano Tollari b c, Giovanni Palmisano b c, Angelo Sironi a. 71: 22-28.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

4-Amino-1H-pyrazole, 1 g

sc-232380
1 g
$130.00