Date published: 2026-4-30

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4-Acetylphenyl isocyanate (CAS 49647-20-3)

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CAS Number:
49647-20-3
Molecular Weight:
161.16
Molecular Formula:
C9H7NO2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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4-Acetylphenyl isocyanate serves as a intermediate in the synthesis of various organic compounds, including pesticides and dyes. Notably, it finds application as a catalyst in the production of polyurethane foams and other polyurethane-based materials. While it exhibits solubility in organic solvents like ethanol and acetone, it remains insoluble in water. This versatile compound is also utilized in the synthesis of other isocyanates, such as 4-chlorophenyl isocyanate and 4-bromophenyl isocyanate. Moreover, 4-Acetylphenyl isocyanate plays a pivotal role in the synthesis of 4-acetylpyridine and its derivatives.


4-Acetylphenyl isocyanate (CAS 49647-20-3) References

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  2. Selective synthesis of eight-membered cyclic ureas by the [6 + 2] cycloaddition reaction of 2-vinylazetidines and electron-deficient isocyanates.  |  Koya, S., et al. 2009. Org Lett. 11: 5438-41. PMID: 19904923
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  4. Improving the antifouling property of polysulfone ultrafiltration membrane by incorporation of isocyanate-treated graphene oxide.  |  Zhao, H., et al. 2013. Phys Chem Chem Phys. 15: 9084-92. PMID: 23644556
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  6. RNA drug discovery: Conformational restriction enhances specific modulation of the T-box riboswitch function.  |  Armstrong, I., et al. 2020. Bioorg Med Chem. 28: 115696. PMID: 33069065
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  8. Hydroboration of isocyanates: cobalt-catalyzed vs. catalyst-free approaches.  |  Gudun, KA., et al. 2022. Org Biomol Chem. 20: 6821-6830. PMID: 35968649
  9. Antiinflammatory 3,4-dihydro-2-alkyl-3-oxo-2H-1,2-benzothiazine-4-carboxamide 1,1-dioxides.  |  Lombardino, JG. and Wiseman, EH. 1971. J Med Chem. 14: 973-7. PMID: 5115698
  10. Guanylhydrazones with potential antileukemic activity. 2. Synthesis and structure-activity relationships of analogues of 4,4'-diacetyl-N,N'-diphenylurea bis(guanylhydrazone).  |  Korytnyk, W., et al. 1978. J Med Chem. 21: 507-13. PMID: 580938
  11. Synthesis and exfoliation of isocyanate-treated graphene oxide nanoplatelets  |  Sasha Stankovich a, Richard D. Piner a, SonBinh T. Nguyen b, Rodney S. Ruoff a. 2006, Pages. Carbon. 44: 3342-3347.
  12. Nanocomposites based on polyurethanes and carbon nanoparticles: preparation, properties and application  |  Elmira Badamshina,*a Yakov Estrina and Margarita Gafurovaa. 2013. J. Mater. Chem. A. 1: 6509-6529.
  13. Catalytic ship-in-a-bottle assembly within hollow porous nanocapusles  |  Nasim Ehterami,a Sergey A. Dergunov,a Yenlik Ussipbekova,b Vladimir B. Birmanc and Eugene Pinkhassik*a . 2014. New J. Chem. 38: 481-485.
  14. Nucleophilic Difluoroalkylation of Isocyanates with Difluoromethyl 2-Pyridyl Sulfone  |  Shan Li, Peng Peng, Jun Wei, Yongzhou Hu, Jinbo Hu, Rong Sheng. 2015. Advanced Synthesis. 357: 3429-3434.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

4-Acetylphenyl isocyanate, 1 g

sc-232371
1 g
$51.00