Molecular structure of 4-Acetyl-1,1-dimethylpiperazinium iodide, CAS Number: 75667-84-4
4-Acetyl-1,1-dimethylpiperazinium iodide (CAS 75667-84-4)
Application:
4-Acetyl-1,1-dimethylpiperazinium iodide is an AChR agonist
CAS Number:
75667-84-4
Molecular Weight:
284.14
Molecular Formula:
C8N17IN2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
4-Acetyl-1,1-dimethylpiperazinium iodide is a structural analog of acetylcholine that acts as an AChR agonist (Ki = 29.9 nM at α4β2). It upregulates the number of α4β2 binding sites in M10 cells in vitro by 440%.
4-Acetyl-1,1-dimethylpiperazinium iodide (CAS 75667-84-4) References
- Binding of semirigid nicotinic agonists to nicotinic and muscarinic receptors. | Spivak, CE., et al. 1989. Mol Pharmacol. 36: 177-84. PMID: 2747625
- Vasoactive intestinal peptide-expressing interneurons are impaired in a mouse model of Dravet syndrome. | Goff, KM. and Goldberg, EM. 2019. Elife. 8: PMID: 31282864
- Structural and electronic requirements for potent agonists at a nicotinic receptor. | Spivak, CE., et al. 1986. Eur J Pharmacol. 120: 127-31. PMID: 3485051
- Interaction between acetylcholine and other agonists at cholinoreceptive membrane of mollusc neurons. | Vulfius, CA., et al. 1980. Brain Res. 200: 190-4. PMID: 7417805
- Regulation of nicotinic receptor subtypes following chronic nicotinic agonist exposure in M10 and SH-SY5Y neuroblastoma cells. | Warpman, U., et al. 1998. J Neurochem. 70: 2028-37. PMID: 9572289
Activator of:
AChR α 4, and AChRbeta2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4-Acetyl-1,1-dimethylpiperazinium iodide, 10 mg | sc-203473 | 10 mg | $115.00 | |||
4-Acetyl-1,1-dimethylpiperazinium iodide, 50 mg | sc-203473A | 50 mg | $473.00 |