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4,4′-Methylenebis(2,6-dimethylphenol) (CAS 5384-21-4)

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Alternate Names:
Bis(4-hydroxy-3,5-dimethylphenyl)methane; 4,4′-Dihydroxy-3,3′,5,5′-tetramethyldiphenylmethane
CAS Number:
5384-21-4
Molecular Weight:
256.35
Molecular Formula:
C17H20O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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4,4′-Methylenebis(2,6-dimethylphenol), known as MBDM, is a phenolic compound that has been used in various scientific research applications. It is an important intermediate in organic synthesis and is widely used in the manufacture of polymers, plastics, synthetic fibers, agrochemicals, and dyes. 4,4′-Methylenebis(2,6-dimethylphenol) may act to inhibit the activity of certain enzymes, such as cyclooxygenase and lipoxygenase, which are involved in the synthesis of prostaglandins and leukotrienes. In addition, it can bind to certain receptors, such as the 5-HT2A receptor, which is involved in the regulation of serotonin levels in the brain. Studies have also found anti-inflammatory and antioxidant activities.


4,4′-Methylenebis(2,6-dimethylphenol) (CAS 5384-21-4) References

  1. Overgeneralization by Mesnage et al. Regarding Bisphenol A Alternatives.  |  Soto, AM., et al. 2017. Toxicol Sci. 160: 2. PMID: 28973518
  2. Identification of Three Dalbergia Species Based on Differences in Extractive Components.  |  Yin, X., et al. 2018. Molecules. 23: PMID: 30154322
  3. Self-immolative polymers with potent and selective antibacterial activity by hydrophilic side chain grafting.  |  Ergene, C. and Palermo, EF. 2018. J Mater Chem B. 6: 7217-7229. PMID: 32254634
  4. Comparative toxicities of BPA, BPS, BPF, and TMBPF in the nematode Caenorhabditis elegans and mammalian fibroblast cells.  |  Hyun, M., et al. 2021. Toxicology. 461: 152924. PMID: 34474090
  5. Radical reactions in the co‐ordination sphere of transition metals. XIII Radicals derived from 4, 4′‐and 2, 2′‐Alkylidenebisphenolic Antioxidants  |  Omelka, L., Tkáč, A., Jiráčková, L., & Pospíšil, J. 1982. Organic Magnetic Resonance. 19(3): 153-159.
  6. Simple, non-catalytic permethylation of catechol derivatives in subcritical and supercritical water  |  Wang, P., Nishimura, D., Komatsu, T., & Kobiro, K. 2011. The Journal of Supercritical Fluids. 58(3): 360-364.
  7. Self-crosslinked alkaline electrolyte membranes based on quaternary ammonium poly (ether sulfone) for high-performance alkaline fuel cells  |  Sun, H., Zhang, G., Liu, Z., Zhang, N., Zhang, L., Ma, W.,.. & Na, H. 2012. International journal of hydrogen energy. 37(12): 9873-9881.
  8. Synthesis, oxidation and crosslinking of tetramethyl bisphenol F (TMBPF)-based polymers for oxygen/nitrogen gas separations  |  Sundell, B. J., Shaver, A. T., Liu, Q., Nebipasagil, A., Pisipati, P., Mecham, S. J.,.. & McGrath, J. E. 2014. Polymer. 55(22): 5623-5634.
  9. Gas transport properties and characterization of UV crosslinked poly (phenylene oxide-co-arylene ether ketone) copolymers  |  Rowlett, J. R., Liu, Q., Zhang, W., Moon, J. D., Dose, M. E., Riffle, J. S.,.. & McGrath, J. E. 2016. Journal of Materials Chemistry A. 4(41): 16047-16056.
  10. Effects of minerals on metamorphism of organic matter during thermal processes in meteorite parent bodies  |  Hirakawa, N., Kebukawa, Y., Kobayashi, K., & Nakano, H. 2021. Icarus. 358: 114167.
  11. Synthesis of Cyclic Polyolefin: Ring‐Opening Metathesis Polymerization by Binuclear Vanadium Complexes  |  Hou, X., Chen, X., Gao, X., Xu, L., Zou, H., Zhou, L., & Wu, Z. Q. 2021. Chinese Journal of Chemistry. 39(5): 1181-1187.
  12. Mechanism analysis of methanol alcoholysis of Naomaohu lignite extraction residue based on model compound reaction path  |  YANG, W. Q., MAO, K. M., MO, W. L., WEI, X. Y., Xin, F. A. N., & REN, T. Z. 2022. Journal of Fuel Chemistry and Technology. 50(4): 396-407.
  13. One-step green synthesis of hybrid Fe-Mn nanoparticles: Methodology, characterization and mechanism  |  Chen, W., Wu, J., Weng, X., Owens, G., & Chen, Z. 2022. Journal of Cleaner Production. 363: 132406.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

4,4′-Methylenebis(2,6-dimethylphenol), 25 g

sc-487859
25 g
$101.00