Date published: 2025-10-1

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4,4′-MDI (CAS 101-68-8)

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Alternate Names:
4,4′-Methylenebis(phenyl isocyanate)
CAS Number:
101-68-8
Purity:
≥97%
Molecular Weight:
250.25
Molecular Formula:
CH2(C6H4NCO)2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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4,4′-MDI serves as a organic compound extensively utilized in the synthesis of polyurethane polymers and various polymeric materials. As a colorless, crystalline solid, 4,4′-MDI exhibits solubility in organic solvents. Additionally, MDI acts as a vital intermediate in the synthesis of polymers, resins, coatings, and adhesives. It enables researchers to investigate the properties of polyurethane polymers and other materials, including their thermal and mechanical characteristics. Moreover, 4,4′-MDI facilitates the exploration of how various additives impact the properties of polymers and other polymeric materials. As a reactive chemical, 4,4′-MDI engages in reactions with other molecules to form polyurethane polymers and other polymeric materials. These reactions involve the creation of urethane linkages, covalent bonds between the 4,4′-MDI molecule and other molecules. Alkaline catalysts, like potassium hydroxide, catalyze these reactions, accelerating the formation of these polymeric materials.


4,4′-MDI (CAS 101-68-8) References

  1. Assessment of dermal uptake of diphenylmethane-4,4'-diisocyanate using tape stripping and biological monitoring.  |  Hamada, H., et al. 2018. Eur J Dermatol. 28: 143-148. PMID: 29620002
  2. LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.  |  Wisnewski, AV., et al. 2019. EC Pharmacol Toxicol. 7: 205-219. PMID: 31143884
  3. Magnetic Polyurea Nano-Capsules Synthesized via Interfacial Polymerization in Inverse Nano-Emulsion.  |  Natour, S., et al. 2019. Molecules. 24: PMID: 31340486
  4. Properties of Novel Polyesters Made from Renewable 1,4-Pentanediol.  |  Stadler, BM., et al. 2020. ChemSusChem. 13: 556-563. PMID: 31794106
  5. Reactivity of Aliphatic and Phenolic Hydroxyl Groups in Kraft Lignin towards 4,4' MDI.  |  Antonino, LD., et al. 2021. Molecules. 26: PMID: 33917247
  6. Catalytic Hydrogenation of Polyurethanes to Base Chemicals: From Model Systems to Commercial and End-of-Life Polyurethane Materials.  |  Gausas, L., et al. 2021. JACS Au. 1: 517-524. PMID: 34467313
  7. Nonaqueous Emulsion Polycondensation Enabled by a Self-Assembled Cage-like Surfactant.  |  Ganta, S., et al. 2022. Chemistry. 28: e202104228. PMID: 35018672
  8. Purification of MDI Isomers Using Dynamic Falling Film Melt Crystallization: Experiment and Molecular Simulation.  |  Lian, X., et al. 2022. ACS Omega. 7: 21492-21504. PMID: 35785319
  9. Isocyanates may contribute to allergic contact dermatitis from diabetes devices and wound dressings.  |  Dendooven, E., et al. 2022. Contact Dermatitis. 87: 414-419. PMID: 35815495
  10. Domain Structure, Thermal and Mechanical Properties of Polycaprolactone-Based Multiblock Polyurethane-Ureas under Control of Hard and Soft Segment Lengths.  |  Bugrov, AN., et al. 2022. Polymers (Basel). 14: PMID: 36236094
  11. Subcritical Hydrothermal Liquefaction as a Pretreatment for Enzymatic Degradation of Polyurethane.  |  Gallorini, R., et al. 2022. ACS Omega. 7: 37757-37763. PMID: 36312382
  12. 'Catch-Store-Release' Strategy for the Stabilization of 4,4'-Methylene Diphenyl Diisocyanate (4,4'-MDI).  |  Dissanayake, AI., et al. 2023. Chemistry. 29: e202300924. PMID: 36971400
  13. Recent advances in synthesis of polymers based on palm oil and its fatty acids.  |  Stavila, E., et al. 2023. RSC Adv. 13: 14747-14775. PMID: 37197178

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

4,4′-MDI, 100 mg

sc-233047
100 mg
$70.00