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β-Catenin/Tcf Inhibitor, FH535 is a sulfonamide-based and cell-permeable compound that exhibits a dual pathway inhibition against Wnt/beta-catenin and PPAR. β-Catenin/Tcf Inhibitor, FH535 and its structurally similar analog, PPAR inhibitor GW9662, both exhibit inhibition of coactivator/PPAR binding, though only β-Catenin/Tcf Inhibitor, FH535 blocks beta-catenin/PPAR interaction. Further, the antagonistic activity of β-Catenin/Tcf Inhibitor, FH535 does not involve the covalent modification of non-covalent interaction with the PPR ligand-binding site cysteine residue, which has been experimentally shown to be for GW9662 action. β-Catenin/Tcf Inhibitor, FH535 is an inhibitor of GRIP1, PPAR-β, and PPAR-γ.
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Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4-(4-Methoxyphenoxy)aniline hydrochloride, 500 mg | sc-314656 | 500 mg | $294.00 |