Date published: 2026-5-3

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4,4-Dimethyl Retinoic Acid (CAS 104182-09-4)

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Alternate Names:
SRI 5397-41X
CAS Number:
104182-09-4
Molecular Weight:
328.49
Molecular Formula:
C22H32O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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4,4-Dimethyl Retinoic Acid is a synthetic analog of retinoic acid, a metabolite of vitamin A (retinol) that plays a role in regulating cell growth, differentiation, and apoptosis. Retinoic acid and its analogs are known for their ability to modulate gene expression through retinoic acid receptors (RARs) and retinoid X receptors (RXRs), which are nuclear transcription factors. 4,4-Dimethyl Retinoic Acid can serve as an internal standard in chromatographic analyses for the accurate handling and measurement of all-trans retinoic acid and its isomers. The distinction between all-trans retinoic acid and cis-isomers of retinoic acid is for the accurate identification and quantification of all-trans retinoic acid and its isomers in biological samples, with 4,4-Dimethyl Retinoic Acid playing a key role in ensuring the integrity of the analysis.


4,4-Dimethyl Retinoic Acid (CAS 104182-09-4) References

  1. Rdh12 activity and effects on retinoid processing in the murine retina.  |  Chrispell, JD., et al. 2009. J Biol Chem. 284: 21468-77. PMID: 19506076
  2. Quantification of endogenous retinoids.  |  Kane, MA. and Napoli, JL. 2010. Methods Mol Biol. 652: 1-54. PMID: 20552420
  3. Insulin regulates retinol dehydrogenase expression and all-trans-retinoic acid biosynthesis through FoxO1.  |  Obrochta, KM., et al. 2015. J Biol Chem. 290: 7259-68. PMID: 25627686
  4. Proteomics of Non-human Primate Plasma after Partial-body Radiation with Minimal Bone Marrow Sparing.  |  Huang, W., et al. 2020. Health Phys. 119: 621-632. PMID: 32947488
  5. Alteration of circadian machinery in monocytes underlies chronic kidney disease-associated cardiac inflammation and fibrosis.  |  Yoshida, Y., et al. 2021. Nat Commun. 12: 2783. PMID: 33986294

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

4,4-Dimethyl Retinoic Acid, 0.5 mg

sc-498131
0.5 mg
$354.00

4,4-Dimethyl Retinoic Acid, 1 mg

sc-498131A
1 mg
$666.00

4,4-Dimethyl Retinoic Acid, 2.5 mg

sc-498131B
2.5 mg
$1493.00

4,4-Dimethyl Retinoic Acid, 10 mg

sc-498131C
10 mg
$5722.00

4,4-Dimethyl Retinoic Acid, 25 mg

sc-498131D
25 mg
$14045.00