Date published: 2026-3-12

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4,4-Dimethyl-2-phenyl-2-oxazoline (CAS 19312-06-2)

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CAS Number:
19312-06-2
Molecular Weight:
175.23
Molecular Formula:
C11H13NO
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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4,4-Dimethyl-2-phenyl-2-oxazoline functions as a chiral ligand in asymmetric catalysis. It acts as a chelating agent, coordinating with transition metal catalysts to facilitate enantioselective reactions. The oxazoline moiety of the compound interacts with the metal center, enabling the formation of stable complexes that can participate in a variety of asymmetric transformations. Through its coordination with the metal catalyst, 4,4-Dimethyl-2-phenyl-2-oxazoline plays a key role in controlling the stereochemistry of the reaction, leading to the formation of chiral products with high enantiomeric excess. 4,4-Dimethyl-2-Phenyl-2-Oxazoline′s mechanism of action involves the formation of a complex with the metal catalyst, which then interacts with the substrate to induce asymmetric induction and promote the desired stereochemical outcome. In this way, 4,4-Dimethyl-2-phenyl-2-oxazoline serves as useful in the development of enantioselective synthesis methodologies, contributing to the advancement of asymmetric catalysis in chemical research.


4,4-Dimethyl-2-phenyl-2-oxazoline (CAS 19312-06-2) References

  1. Half-sandwich cycloruthenated complexes from aryloxazolines: synthesis, structures, and catalytic activities.  |  Jia, WG., et al. 2016. Dalton Trans. 45: 14230-7. PMID: 27534600
  2. Sodium Diisopropylamide in Tetrahydrofuran: Selectivities, Rates, and Mechanisms of Arene Metalations.  |  Algera, RF., et al. 2017. J Am Chem Soc. 139: 15197-15204. PMID: 28946744
  3. Case for Lithium Tetramethylpiperidide-Mediated Ortholithiations: Reactivity and Mechanisms.  |  Mack, KA. and Collum, DB. 2018. J Am Chem Soc. 140: 4877-4883. PMID: 29589920

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

4,4-Dimethyl-2-phenyl-2-oxazoline, 10 g

sc-226807
10 g
$136.00