4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (CAS 3945-69-5)
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Superior or comparable to the most popular coupling reagents reagent for activating carboxylic acids in solution and solid phase peptide synthesis. It is a yellowish-white powder that is easily soluble in water and other polar solvents. It′s used to create amides and esters through a single-step process. This compound is known for its selectivity, high yields, and its capability to be easily evacuated from the reaction mixture under reduced pressure. It plays a pivotal role in activating carboxyl polysaccharides for glucan production, functionalizing poly(acrylic acid) and poly(methacrylic acid) with amines to form amide bonds, producing glycoconjugates, and in linking propylamine and butylamine to hyaluronic acid. Additionally, it acts as a conjugating agent, effectively attaching PnPS to Luminex microspheres while preserving the antigenicity of a broad set of PnPS. It can be used as a coupling agent, a deprotection agent, or a cross-linking reagent, depending on the specific requirements of the reaction.
4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (CAS 3945-69-5) References
- A racemization test in peptide synthesis using 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (DMT-MM). | Kunishima, M., et al. 2002. Chem Pharm Bull (Tokyo). 50: 549-50. PMID: 11964009
- Preparation of Weinreb amides using 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (DMT-MM). | Hioki, K., et al. 2004. Chem Pharm Bull (Tokyo). 52: 470-2. PMID: 15056969
- Solid phase peptide synthesis in water VI: evaluation of water-soluble coupling reagents for solid phase peptide synthesis in aqueous media. | Hojo, K., et al. 2006. Protein Pept Lett. 13: 189-92. PMID: 16472083
- Novel acyclic amide-conjugated nucleosides and their analogues. | Boncel, S. and Walczak, K. 2009. Nucleosides Nucleotides Nucleic Acids. 28: 103-17. PMID: 19219740
- An in-depth analysis of polymer-analogous conjugation using DMTMM. | Pelet, JM. and Putnam, D. 2011. Bioconjug Chem. 22: 329-37. PMID: 21309584
- One-pot preparation of Oxazol-5(4H)-ones from amino acids in aqueous solvents. | Fujita, H. and Kunishima, M. 2012. Chem Pharm Bull (Tokyo). 60: 907-12. PMID: 22790826
- Aqueous microwave-assisted solid-phase peptide synthesis using Fmoc strategy. III: racemization studies and water-based synthesis of histidine-containing peptides. | Hojo, K., et al. 2014. Amino Acids. 46: 2347-54. PMID: 24965528
- 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride as an enantioseparation enhancer for fluorescence chiral derivatization-liquid chromatographic analysis of dl-lactic acid. | Todoroki, K., et al. 2014. J Chromatogr A. 1360: 188-95. PMID: 25115455
- Effect of the molecular architecture on the thermosensitive properties of chitosan-g-poly(N-vinylcaprolactam). | Fernández-Quiroz, D., et al. 2015. Carbohydr Polym. 134: 92-101. PMID: 26428104
- Enhancing hyaluronan pseudoplasticity via 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride-mediated conjugation with short alkyl moieties. | Petta, D., et al. 2016. Carbohydr Polym. 151: 576-583. PMID: 27474602
- Chemo-enzymatic synthesis of a glycosylated peptide containing a complex N-glycan based on unprotected oligosaccharides by using DMT-MM and Endo-M. | Tomabechi, Y., et al. 2017. Glycoconj J. 34: 481-487. PMID: 28523604
- Expanding the Scope of Cross-Link Identifications by Incorporating Collisional Activated Dissociation and Ultraviolet Photodissociation Methods. | Cammarata, MB., et al. 2018. Anal Chem. 90: 6385-6389. PMID: 29722964
- A Screening Method for Cyanide in Blood by Dimethoxytriazinyl Derivatization-GC/MS. | Yamaguchi, A. and Miyaguchi, H. 2021. J Chromatogr Sci. 59: 1-6. PMID: 33147618
- 2-Dimensional ultra-high performance liquid chromatography and DMT-MM derivatization paired with tandem mass spectrometry for comprehensive serum N-glycome characterization. | Smith, J., et al. 2021. Anal Chim Acta. 1179: 338840. PMID: 34535264
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride, 1 g | sc-252089 | 1 g | $64.00 |