Date published: 2025-10-15

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4,4,4-Trifluoro-butan-1-ol (CAS 461-18-7)

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CAS Number:
461-18-7
Molecular Weight:
128.09
Molecular Formula:
C4H7F3O
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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4,4,4-Trifluoro-butan-1-ol (TFB) is a versatile chemical compound employed extensively as both a reagent in organic synthesis. This colorless liquid exhibits volatility and emits a pleasant fruity scent. Its low boiling point and flammability render it a valuable reagent in numerous laboratory experiments. Additionally referred to as trifluorobutanol, trifluorobutanolide, and trifluorobutyl alcohol, 4,4,4-Trifluoro-butan-1-ol finds wide application in scientific research as a reagent and solvent. 4,4,4-Trifluoro-butan-1-ol proves particularly valuable in organic synthesis due to its high reactivity and low boiling point. Its inclusion facilitates the formation of new compounds through reactions with other compounds. For instance, 4,4,4-Trifluoro-butan-1-ol can react with aldehydes and ketones, resulting in the formation of alcohols. Moreover, when combined with carboxylic acids, 4,4,4-Trifluoro-butan-1-ol gives rise to esters. Furthermore, 4,4,4-Trifluoro-butan-1-ol exhibits the capability to form halohydrins through reactions with halogens and to generate amines when reacted with nitrogen-containing compounds. Its solvent properties find utility in various applications, facilitating efficient dissolution and processing.


4,4,4-Trifluoro-butan-1-ol (CAS 461-18-7) References

  1. Enantioselective synthesis of (2R, 3S)- and (2S, 3R)-4,4,4-trifluoro-N-Fmoc-O-tert-butyl-threonine and their racemization-free incorporation into oligopeptides via solid-phase synthesis.  |  Xiao, N., et al. 2007. Biopolymers. 88: 781-96. PMID: 17702025

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

4,4,4-Trifluoro-butan-1-ol, 5 g

sc-262185
5 g
$222.00

4,4,4-Trifluoro-butan-1-ol, 25 g

sc-262185A
25 g
$801.00