4-(2-Cyclohexylethoxy)-2-methylaniline
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Sodium phenylbutyrate, an HDAC (histone deacetylase) inhibitor, causes cellular differentiation, growth arrest, and apoptosis in certain cells. It has been reported to cause cell growth arrest at the G1 phase and induce apoptosis through activation of JNK. Studies suggest that Sodium phenylbutyrate also acts as a chemical chaperone by causing a reduction of the load of mutant and mislocated proteins retained in the endoplasmic reticulum (ER). Other experiments have noted that it demonstrates neuroprotective capabilities by attenuating infarction volume, apoptosis, hemispheric swelling and improving neurological status in a murine model of hypoxia-ischemia. Moreover, Sodium phenylbutyrate may act to suppress ER-mediated apoptosis by initiating factor 2α phosphorylation, caspase-12 activation, and CCAAT/enhancer-binding protein homologous protein induction.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4-(2-Cyclohexylethoxy)-2-methylaniline, 500 mg | sc-313963 | 500 mg | $294.00 |