4-(2,4-Dichlorophenoxy)butanohydrazide
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Chrysomycin A is the major analogue in a complex of C-glycoside antitumor actives found in Streptomyces sp. Chrysomycin A, with a vinyl group in the 8-position, is the most potent analogue of the complex. It was shown to mediate a unique cross-linking reaction between DNA and histidine H3. Also shown to be an antineoplastic and photosensitizing compound. It is thought to act as an inhibitor of the catalytic activity of human Topo II (topoisomerase II). Chrysomyin A has a potent antibacterial, antifungal, antiviral and antitumor profile. Exhibits antitumor activity against human cell lines K562, HT29, MCF7, PC6, and MKN28. More recent research on related metabolites, the gilvocarcins, suggests that chrysomycins may act as photoactivated crosslinkers of DNA to histones.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4-(2,4-Dichlorophenoxy)butanohydrazide, 500 mg | sc-314194 | 500 mg | $146.00 |