4.1B Antibody (F-11): sc-398084

4.1B Antibody (F-11) is a mouse monoclonal IgG1 antibody that detects 4.1B in mouse samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). 4.1B, also known as EPB41L3, is a member of the 4.1 gene family, which encodes a group of multifunctional cytoskeletal proteins that play crucial roles in maintaining cell shape and mechanical properties. 4.1B is predominantly expressed in the brain and is particularly important for its involvement in the stabilization of the spectrin-actin cytoskeleton, which is essential for the structural integrity of neuronal cells. The unique distribution of 4.1B in the cerebellum suggests that 4.1B may modulate the mechanical properties of neuronal membranes, thereby influencing synaptic function and plasticity. Additionally, 4.1B interacts with other cytoskeletal proteins, contributing to the formation of specialized membrane domains that are vital for effective neuronal signaling. The ability of anti-4.1B antibody (F-11) to detect multiple forms in brain preparations highlights 4.1B′s significance in studying synaptic structures and functions, making anti-4.1B antibody (F-11) an invaluable tool for researchers investigating the complexities of neuronal architecture and dynamics.

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4.1B Antibody (F-11) References:

1. The 4.1/ezrin/radixin/moesin domain of the DAL-1/Protein 4.1B tumour suppressor interacts with 14-3-3 proteins.  |  Yu, T., et al. 2002. Biochem J. 365: 783-9. PMID: 11996670
2. Protein 4.1B associates with both Caspr/paranodin and Caspr2 at paranodes and juxtaparanodes of myelinated fibres.  |  Denisenko-Nehrbass, N., et al. 2003. Eur J Neurosci. 17: 411-6. PMID: 12542678
3. DAL-1/4.1B tumor suppressor interacts with protein arginine N-methyltransferase 3 (PRMT3) and inhibits its ability to methylate substrates in vitro and in vivo.  |  Singh, V., et al. 2004. Oncogene. 23: 7761-71. PMID: 15334060
4. Protein 4.1B/differentially expressed in adenocarcinoma of the lung-1 functions as a growth suppressor in meningioma cells by activating Rac1-dependent c-Jun-NH(2)-kinase signaling.  |  Gerber, MA., et al. 2006. Cancer Res. 66: 5295-303. PMID: 16707455
5. Evidence for protein 4.1B acting as a metastasis suppressor.  |  Cavanna, T., et al. 2007. J Cell Sci. 120: 606-16. PMID: 17264155
6. A Golgi-associated protein 4.1B variant is required for assimilation of proteins in the membrane.  |  Kang, Q., et al. 2009. J Cell Sci. 122: 1091-9. PMID: 19299464
7. The cytoskeletal adaptor protein band 4.1B is required for the maintenance of paranodal axoglial septate junctions in myelinated axons.  |  Buttermore, ED., et al. 2011. J Neurosci. 31: 8013-24. PMID: 21632923
8. Ablation of cytoskeletal scaffolding proteins, Band 4.1B and Whirlin, leads to cerebellar purkinje axon pathology and motor dysfunction.  |  Saifetiarova, J. and Bhat, MA. 2019. J Neurosci Res. 97: 313-331. PMID: 30447021
9. [Corrigendum] Pivotal roles of protein 4.1B/DAL‑1, a FERM‑domain containing protein, in tumor progression (Review).  |  Yuan, X., et al. 2020. Int J Oncol. 56: 641. PMID: 31814035
10. The prognostic value of 4.1 mRNA expression in non-small cell lung cancer.  |  Xiang, Y., et al. 2021. Transl Cancer Res. 10: 1216-1228. PMID: 35116449

The preferred 4.1B antibody is 4.1B Antibody (B-6): sc-398089.