4-(1-Amino-ethyl)-hepta-1,6-dien-4-ol hydrochloride
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Gliotoxin is an epipolythiodioxopiperazine metabolite. This agent displays a capacity to induce macrophagocytic, thymocytic, splenocytic, and mesenteric lymph node cell apoptosis and inhibit transcription factor NF-kappaB activation. Mechanistic studies suggest that this inhibition is done via a suppression of proteasome-mediated degradation of IkappaB-alpha. Additional research reports that Gliotoxin is capable of down-regulating inflammation and suppressing TNFalpha IL-1alpha and mRNA expression. Gliotoxin is an inhibitor of Farnesyl Transferase and GGTase. Gliotoxin is an inhibitor of 20S Proteasome. Gliotoxin exhibits inhibitory activities against histone H3K9 methyltransferase, a key enzyme in the regulation of transcriptional activity by writing epigenetic marks.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4-(1-Amino-ethyl)-hepta-1,6-dien-4-ol hydrochloride, 500 mg | sc-313804 | 500 mg | $284.00 |