4-[(2-Chlorophenoxy)methyl]piperidinehydrochloride (CAS 614731-37-2)
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LY 364947 is a diheteroaryl-substituted pyrazole compound used as a selective, ATP-competitive inhibitor of TGF-betaRI (TGF-beta Receptor I kinase). Studies of mouse fibroblasts show that LY 364947 inhibits cellular growth and transcription activation via TGF-beta Receptor I kinase inhibition. In addition, TGF-beta Receptor I kinase is responsible for fibroblast proliferation and the accumulation of astrocytes around the fibrotic scar when injury occurs to cells. In vitro studies report that in the presence of LY 364947 the amount of reactive astrocytes at the lesion site is also reduced. Furthermore, studies show that LY 364947 strongly effects intraplug vasculature by increasing the extravasation of Dextran (sc-218165). LY 364947 is an inhibitor of eIF2 alpha, MLTK, p38 alpha and TGF beta RII.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4-[(2-Chlorophenoxy)methyl]piperidinehydrochloride, 500 mg | sc-315107 | 500 mg | $259.00 |