3‴,5‴-Dideshydroxy-3‴,5‴-dimethoxy Fidaxomicin (CAS 185248-68-4)

3‴,5‴-Dideshydroxy-3‴,5‴-dimethoxy Fidaxomicin is a chemically modified derivative of fidaxomicin, originally derived from the actinomycete Dactylosporangium aurantiacum. This derivative is designed to probe the structure-activity relationships within fidaxomicin analogs and enhance the understanding of its biochemical behavior, particularly in its interactions with bacterial enzymes. The primary mechanism of action of this derivative, like fidaxomicin, involves inhibiting bacterial RNA polymerase, though with modifications that may affect its binding affinity or specificity. By targeting RNA polymerase, this compound disrupts the transcription process essential for bacterial RNA synthesis. The specific modifications in this derivative, particularly the removal of hydroxyl groups and the addition of methoxy groups at designated positions, are intended to study how these changes influence the compound′s efficacy and interaction with the target enzyme. In scientific research, 3‴,5‴-Dideshydroxy-3‴,5‴-dimethoxy Fidaxomicin has been used to dissect the role of specific functional groups in binding interactions and enzyme inhibition. These studies are crucial for understanding how molecular alterations can modulate the activity of biochemical agents against bacterial targets. Insights gained from such research can lead to the development of more effective derivatives and provide a deeper understanding of molecular mechanisms that govern enzyme inhibition by antibiotics.