Molecular structure of 3′-Deoxy-3′-fluorothymidine-5′-monophosphate Disodium Salt
3′-Deoxy-3′-fluorothymidine-5′-monophosphate Disodium Salt
Application:
3′-Deoxy-3′-fluorothymidine-5′-monophosphate Disodium Salt is a thymidine-5′-O-monophosphate analogue
Molecular Weight:
368.16
Molecular Formula:
C10H12FN2Na2O7P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
3′-Deoxy-3′-fluorothymidine-5′-monophosphate Disodium Salt is the disodium salt preparation of the fluoronated thymidine-5′-O-monophosphate analog 3′-Deoxy-3′-fluorothymidine-5′-monophosphate. 3′-Deoxy-3′-fluorothymidine-5′-monophosphate is described to be a substrate of Mycobacterium tuberculosis thymidylate kinase with a Km of 30 uM.
3′-Deoxy-3′-fluorothymidine-5′-monophosphate Disodium Salt References
- X-ray structure of TMP kinase from Mycobacterium tuberculosis complexed with TMP at 1.95 A resolution. | Li de la Sierra, I., et al. 2001. J Mol Biol. 311: 87-100. PMID: 11469859
- Synthesis and evaluation of thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase. | Vanheusden, V., et al. 2002. Bioorg Med Chem Lett. 12: 2695-8. PMID: 12217356
- Comparisons of anti-human immunodeficiency virus activities, cellular transport, and plasma and intracellular pharmacokinetics of 3'-fluoro-3'-deoxythymidine and 3'-azido-3'-deoxythymidine. | Kong, XB., et al. 1992. Antimicrob Agents Chemother. 36: 808-18. PMID: 1503443
- Monitoring cellular accumulation of 3'-deoxy-3'-fluorothymidine (FLT) and its monophosphate metabolite (FLT-MP) by LC-MS/MS as a measure of cell proliferation in vitro. | Li, W., et al. 2011. J Chromatogr B Analyt Technol Biomed Life Sci. 879: 2963-70. PMID: 21925976
- Liquid chromatography-tandem mass spectrometry method for quantification of thymidine kinase activity in human serum by monitoring the conversion of 3'-deoxy-3'-fluorothymidine to 3'-deoxy-3'-fluorothymidine monophosphate. | Faria, M., et al. 2012. J Chromatogr B Analyt Technol Biomed Life Sci. 907: 13-20. PMID: 22995377
- The CDC8 gene of yeast encodes thymidylate kinase. | Jong, AY., et al. 1984. J Biol Chem. 259: 11052-9. PMID: 6088527
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3'-Deoxy-3'-fluorothymidine-5'-monophosphate Disodium Salt, 1 mg | sc-216619 | 1 mg | $400.00 |