Molecular structure of 3′-Deoxy-3′-fluorothymidine, CAS Number: 25526-93-6
3′-Deoxy-3′-fluorothymidine (CAS 25526-93-6)
Alternate Names:
Alovudine; 3′-Fluoro-3′-deoxythymidine; 3′-Fluorothymidine; CL 184824; FLT; MIV 310; NSC 140025
Application:
3′-Deoxy-3′-fluorothymidine is An antiviral agent
CAS Number:
25526-93-6
Molecular Weight:
244.22
Molecular Formula:
C10H13FN2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
3′-Deoxy-3′-fluorothymidine, also called Alovudine, is an antiviral agent and a synthetic nucleoside analogue of thymidine, a naturally occurring pyrimidine nucleoside. It is a member of the nucleoside reverse transcriptase inhibitor (NRTI) family. Alovudine works by inhibiting the activity of HIV-1 and HIV-2 reverse transcriptase, which blocks the conversion of RNA into DNA, thus preventing the virus from replicating. It also inhibits the activity of other enzymes involved in viral replication, such as DNA polymerase, integrase, and the HIV-1 protease.
3′-Deoxy-3′-fluorothymidine (CAS 25526-93-6) References
- Monitoring metabolic responses to chemotherapy in single cells and tumors using nanostructure-initiator mass spectrometry (NIMS) imaging. | O'Brien, PJ., et al. 2013. Cancer Metab. 1: 4. PMID: 24280026
- Preliminary 19F-MRS Study of Tumor Cell Proliferation with 3'-deoxy-3'-fluorothymidine and Its Metabolite (FLT-MP). | Ko, IO., et al. 2017. Contrast Media Mol Imaging. 2017: 3981358. PMID: 29097919
- Using Radiolabeled 3'-Deoxy-3'-18F-Fluorothymidine with PET to Monitor the Effect of Dexamethasone on Non-Small Cell Lung Cancer. | McHugh, CI., et al. 2018. J Nucl Med. 59: 1544-1550. PMID: 29674424
- Integration of High-Resolution Radiation Detector for Hybrid Microchip Electrophoresis. | Jones, J., et al. 2020. Anal Chem. 92: 3483-3491. PMID: 31986878
- Application of human lymphoid cells for the evaluation of antivirals against human adenovirus type 19: Zalcitabine has superior activity compared to cidofovir. | Nakagawara, K., et al. 2020. Antivir Chem Chemother. 28: 2040206620921319. PMID: 32345035
- Nucleotide analogues as inhibitors of SARS-CoV Polymerase. | Ju, J., et al. 2020. Pharmacol Res Perspect. 8: e00674. PMID: 33124786
- 18F-FLT PET/CT as a Prognostic Imaging Biomarker of Disease-Specific Survival in Patients with Primary Soft-Tissue Sarcoma. | Crompton, JG., et al. 2022. J Nucl Med. 63: 708-712. PMID: 34593596
- Role of 3'-Deoxy-3'-[18F] Fluorothymidine Positron Emission Tomography-Computed Tomography as a Predictive Biomarker in Argininosuccinate Synthetase 1-Deficient Thoracic Cancers Treated With Pegargiminase. | Szyszko, TA., et al. 2022. JTO Clin Res Rep. 3: 100382. PMID: 36082278
- Multi-omics revealed rumen microbiota metabolism and host immune regulation in Tibetan sheep of different ages. | Sha, Y., et al. 2024. Front Microbiol. 15: 1339889. PMID: 38414776
Inhibitor of:
HSV-1 Thymidine Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3′-Deoxy-3′-fluorothymidine, 25 mg | sc-220902 | 25 mg | $188.00 |