3′-Azido-3′-deoxythymidine 5′-Monophosphate Sodium Salt (CAS 128506-29-6)
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3′-Azido-3′-deoxythymidine 5′-Monophosphate sodium salt is a compound utilized in biochemical and virology research. It serves as useful for studying the inhibition of certain DNA polymerase enzymes, particularly in the context of viral replication. Researchers use this compound to understand the molecular mechanisms by which viral DNA synthesis is interrupted, which has implications for the study of viral life cycles and replication strategies. In molecular biology, 3′-Azido-3′-deoxythymidine 5′-Monophosphate sodium salt is also used in the investigation of nucleotide analog incorporation into DNA and the resultant effects on DNA stability and function. This compound is further applied in the synthesis of nucleotide and nucleoside analogs, which are of interest for their potential applications in various research fields.
3′-Azido-3′-deoxythymidine 5′-Monophosphate Sodium Salt (CAS 128506-29-6) References
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- Mechanism by which a glutamine to leucine substitution at residue 509 in the ribonuclease H domain of HIV-1 reverse transcriptase confers zidovudine resistance. | Brehm, JH., et al. 2008. Biochemistry. 47: 14020-7. PMID: 19067547
- Pharmacokinetic-pharmacodynamic relationship of NRTIs and its connection to viral escape: an example based on zidovudine. | von Kleist, M. and Huisinga, W. 2009. Eur J Pharm Sci. 36: 532-43. PMID: 19150497
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3′-Azido-3′-deoxythymidine 5′-Monophosphate Sodium Salt, 10 mg | sc-220901 | 10 mg | $350.00 |