3β,5α,6β-Trihydroxycholestane (CAS 1253-84-5)

3β,5α,6β-Trihydroxycholestane (3β,5α,6β-THC) is a naturally occurring triterpenoid steroid molecule present in diverse plant sources, including select species of lichens and mosses. It holds significance as an intermediate compound in the biosynthesis of various steroid hormones. Notably, 3β,5α,6β-Trihydroxycholestane interacts with and activates the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ). This receptor plays a pivotal role in regulating cellular proliferation, differentiation, as well as glucose and lipid metabolism. Upon activation by 3β,5α,6β-Trihydroxycholestane, PPARγ exhibits its anti-inflammatory prowess by impeding the production of inflammatory mediators. Key examples include tumor necrosis factor alpha (TNFα), interleukin 1 β (IL-1β), and cyclooxygenase-2 (COX-2). Through this inhibitory action, 3β,5α,6β-Trihydroxycholestane effectively curtails the levels of these pro-inflammatory factors, contributing to a reduction in inflammatory responses.