Molecular structure of 3-Oxo Citalopram, CAS Number: 372941-54-3
3-Oxo Citalopram (CAS 372941-54-3)
Alternate Names:
1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-3-oxo-5-isobenzofurancarbonitrile
Application:
3-Oxo Citalopram is a useful intermediate of Citalopram
CAS Number:
372941-54-3
Molecular Weight:
338.38
Molecular Formula:
C20H19FN2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
3-Oxo Citalopram is an intermediate of Citalopram (sc-201123). Citalopram is a selective inhibitor of the 5-hydroxytryptamine transporter (serotonin) and therefore is a potent and selective serotonin reuptake inhibitor. Additional studies in indicate that Citalopram may be a weak, allosteric modulator of serotonin in a cross-species chimeric study. Studies also indicate that Citalopram is useful for studying gene expression patterns in circulating lymphocytes. In zebrafish, Citalopram is noted to reduce the frequency of NMDA-induced locomotor rhythm involved in swimming behavor.
3-Oxo Citalopram (CAS 372941-54-3) References
- Plasma membrane monoamine transporters: structure, regulation and function. | Torres, GE., et al. 2003. Nat Rev Neurosci. 4: 13-25. PMID: 12511858
- The effect of citalopram on gene expression profile of Alzheimer lymphocytes. | Palotás, A., et al. 2004. Neurochem Res. 29: 1563-70. PMID: 15260135
- Dissection of an allosteric mechanism on the serotonin transporter: a cross-species study. | Neubauer, HA., et al. 2006. Mol Pharmacol. 69: 1242-50. PMID: 16434615
- Serotonergic modulation of locomotion in zebrafish: endogenous release and synaptic mechanisms. | Gabriel, JP., et al. 2009. J Neurosci. 29: 10387-95. PMID: 19692613
- Identification of biotransformation products of citalopram formed in activated sludge. | Beretsou, VG., et al. 2016. Water Res. 103: 205-214. PMID: 27459150
- Transformation products of citalopram: Identification, wastewater analysis and in silico toxicological assessment. | Osawa, RA., et al. 2019. Chemosphere. 217: 858-868. PMID: 30458421
- Assessment of the presence of transformation products of pharmaceuticals in agricultural environments irrigated with reclaimed water by wide-scope LC-QTOF-MS suspect screening. | Martínez-Piernas, AB., et al. 2021. J Hazard Mater. 412: 125080. PMID: 33540270
- Non-target trend analysis for the identification of transformation products during ozonation experiments of citalopram and four of its biodegradation products. | Nika, MC., et al. 2021. J Hazard Mater. 419: 126401. PMID: 34182420
- Oxidative lactonization of C (sp3)-H bond in methyl aromatic alcohols enabled by proton-coupled electron transfer | Chen, S., Lai, Q., Liu, C., Liu, H., Huang, M., & Cai, S. 2022. Science China Chemistry. 65(8): 1526-1531.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3-Oxo Citalopram, 1 mg | sc-209668 | 1 mg | $360.00 |