3-Oxo-12α-hydroxy-5β-cholanoic Acid (CAS 4185-01-7)

3-Oxo-12α-hydroxy-5β-cholanoic Acid serves as a ligand for two significant nuclear receptors, FXR and LXR. These receptors, FXR and LXR, are transcription factors responsible for regulating the expression of specific genes associated with vital metabolic processes. When 3-Oxo-12α-hydroxy-5β-cholanoic Acid binds to FXR and LXR, it triggers their activation, initiating a series of molecular events. As a result, genes involved in cholesterol, bile acid, and glucose metabolism undergo upregulation, meaning their expression is increased. Simultaneously, genes associated with inflammation and lipid metabolism experience downregulation, leading to a decrease in their expression. Through its interaction with FXR and LXR, 3-Oxo-12α-hydroxy-5β-cholanoic Acid orchestrates a cascade of gene regulation, influencing critical metabolic pathways. The activation of these nuclear receptors by the compound leads to the enhancement of cholesterol, bile acid, and glucose metabolism, while concurrently suppressing inflammation and lipid metabolism-related genes.