Date published: 2025-9-26

1-800-457-3801

SCBT Portrait Logo
Seach Input

3-O-Methyl-L-DOPA Monohydrate (CAS 200630-46-2)

5.0(1)
Write a reviewAsk a question

Alternate Names:
3-O-Methyl-L-DOPA Monohydrate is also known as 3-OMD.
Application:
3-O-Methyl-L-DOPA Monohydrate is the major metabolite of L-DOPA via catechol O-methyltransferase (COMT).
CAS Number:
200630-46-2
Purity:
≥95%
Molecular Weight:
229.23
Molecular Formula:
C10H15NO5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

3-O-Methyl-L-DOPA Monohydrate is often incorporated into research focused on the biochemistry of neurotransmitters, particularly in the context of dopamine metabolism. This compound serves as a metabolite of L-DOPA and is used to study the methylation process carried out by catechol-O-methyltransferase (COMT), an enzyme that plays a significant role in the degradation of catecholamines. In addition, 3-O-Methyl-L-DOPA Monohydrate is involved in research aimed at understanding the blood-brain barrier′s transport mechanisms, as it shares structural similarities with naturally occurring amino acids and neurotransmitters. Researchers also utilize this compound to investigate its influence on dopamine biosynthesis and its potential alterations in various neurological conditions. Furthermore, it acts as a reference material in developing sensitive assays for detecting and quantifying metabolites of L-DOPA in biological samples.


3-O-Methyl-L-DOPA Monohydrate (CAS 200630-46-2) References

  1. Interaction between L-DOPA and 3-O-methyl-L-DOPA for transport in immortalised rat capillary cerebral endothelial cells.  |  Gomes, P. and Soares-da-Silva, P. 1999. Neuropharmacology. 38: 1371-80. PMID: 10471091
  2. The O-methylated derivative of L-DOPA, 3-O-methyl-L-DOPA, fails to inhibit neuronal and non-neuronal aromatic L-amino acid decarboxylase.  |  Soares-da-Silva, P., et al. 2000. Brain Res. 863: 293-7. PMID: 10773222
  3. BIA 3-202, a novel catechol-O-methyltransferase inhibitor, enhances the availability of L-DOPA to the brain and reduces its O-methylation.  |  Parada, A., et al. 2001. Eur J Pharmacol. 420: 27-32. PMID: 11412836
  4. BIA 3-202, a novel catechol-O-methyltransferase inhibitor, reduces the peripheral O-methylation of L-DOPA and enhances its availability to the brain.  |  Parada, A. and Soares-da-Silva, P. 2003. Pharmacology. 68: 29-37. PMID: 12660477
  5. Efficient synthesis of the 18F-labelled 3-O-methyl-6-[18F]fluoro-L-DOPA.  |  Füchtner, F. and Steinbach, J. 2003. Appl Radiat Isot. 58: 575-8. PMID: 12735974
  6. Catechol-O-methyltransferase inhibition in erythrocytes and liver by BIA 3-202 (1-[3,4-dibydroxy-5-nitrophenyl]-2-phenyl-ethanone).  |  Soares-da-Silva, P., et al. 2003. Pharmacol Toxicol. 92: 272-8. PMID: 12787259
  7. Analysis of catecholamines and related substances using porous graphitic carbon as separation media in liquid chromatography-tandem mass spectrometry.  |  Törnkvist, A., et al. 2004. J Chromatogr B Analyt Technol Biomed Life Sci. 801: 323-9. PMID: 14751802
  8. Enzymatic synthesis of L-DOPA alpha-glycosides by reaction with sucrose catalyzed by four different glucansucrases from four strains of Leuconostoc mesenteroides.  |  Yoon, SH., et al. 2010. Carbohydr Res. 345: 1730-5. PMID: 20579635
  9. Delayed O-methylation of l-DOPA in MB-COMT-deficient mice after oral administration of l-DOPA and carbidopa.  |  Tammimäki, A., et al. 2018. Xenobiotica. 48: 325-331. PMID: 28375049
  10. Analytical Method Validation for Estimation of Neurotransmitters (Biogenic Monoamines) from Cerebrospinal Fluid Using High Performance Liquid Chromatography.  |  Lokhande, RV., et al. 2022. Indian J Clin Biochem. 37: 85-92. PMID: 35125697
  11. Cell inward transport of L-DOPA and 3-O-methyl-L-DOPA in rat renal tubules.  |  Soares-da-Silva, P., et al. 1994. Br J Pharmacol. 112: 611-5. PMID: 8075877
  12. Liquid chromatographic analysis of brain homogenates and microdialysates for the quantification of L-[beta-11C]DOPA and its metabolites for the validation of positron emission tomography studies.  |  Lindner, KJ., et al. 1995. J Pharm Biomed Anal. 13: 361-7. PMID: 9696544

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

3-O-Methyl-L-DOPA Monohydrate, 25 mg

sc-206674
25 mg
$360.00

3-O-Methyl-L-DOPA Monohydrate, 50 mg

sc-206674A
50 mg
$725.00

3-O-Methyl-L-DOPA Monohydrate, 100 mg

sc-206674B
100 mg
$1325.00