Date published: 2026-1-13

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3-O-Ethyl-L-ascorbic acid (CAS 86404-04-8)

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CAS Number:
86404-04-8
Purity:
≥99%
Molecular Weight:
204.178
Molecular Formula:
C8H12O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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3-O-Ethyl-L-ascorbic acid is a derivative of L-ascorbic acid. In various studies, 3-O-Ethyl-L-ascorbic acid has been examined for its antioxidant activity, demonstrating its ability to scavenge free radicals and impede the generation of reactive oxygen species. This compound has exhibited cell-protective properties, along with the ability to regulate gene expression and alleviate oxidative stress. Studies show that 3-O-Ethyl-L-ascorbic acid has anti-inflammatory effects and it′s involvement in the regulation of cell proliferation and differentiation.


3-O-Ethyl-L-ascorbic acid (CAS 86404-04-8) References

  1. Allergic contact dermatitis caused by 3-o-ethyl-L-ascorbic acid (vitamin C ethyl).  |  Yagami, A., et al. 2014. Contact Dermatitis. 70: 376-7. PMID: 24846587
  2. A simple efficient synthesis and biological evaluation of 3-O-ethylascorbic acid.  |  Tai, A., et al. 2014. Biosci Biotechnol Biochem. 78: 1984-7. PMID: 25127395
  3. Allergic Contact Dermatitis to 3-o-Ethyl-L-Ascorbic Acid in Skin-lightening Cosmetics.  |  Victoria-Martínez, AM. and Mercader-García, P. 2017. Dermatitis. 28: 89. PMID: 28002235
  4. Problems and solutions of polyethylene glycol co-injection method in multiresidue pesticide analysis by gas chromatography-mass spectrometry: evaluation of instability phenomenon in type II pyrethroids and its suppression by novel analyte protectants.  |  Akutsu, K., et al. 2018. Anal Bioanal Chem. 410: 3145-3160. PMID: 29556739
  5. Suppression of riboflavin-sensitized singlet oxygen generation by l-ascorbic acid, 3-O-ethyl-l-ascorbic acid and Trolox.  |  Shimizu, R., et al. 2019. J Photochem Photobiol B. 191: 116-122. PMID: 30605891
  6. 3-O-ethyl-l-ascorbic acid: Characterisation and investigation of single solvent systems for delivery to the skin.  |  Iliopoulos, F., et al. 2019. Int J Pharm X. 1: 100025. PMID: 31517290
  7. Ascorbic Acid Derivatives as Potential Substitutes for Ascorbic Acid To Reduce Color Degradation of Drinks Containing Ascorbic Acid and Anthocyanins from Natural Extracts.  |  Gérard, V., et al. 2019. J Agric Food Chem. 67: 12061-12071. PMID: 31588743
  8. Allergic contact dermatitis to 3-O-ethyl-L-ascorbic acid: An underrated allergen in cosmetics?  |  Romita, P., et al. 2020. Contact Dermatitis. 83: 63-64. PMID: 32208530
  9. A rare case of allergic contact dermatitis caused by 3-O-ethyl-L-ascorbic acid in skin-whitening cosmetics identified under immunosuppressive therapy.  |  Hamanaka, M., et al. 2020. Contact Dermatitis. 83: 520-521. PMID: 32617988
  10. A comparison of the in vitro permeation of 3-O-ethyl-l-ascorbic acid in human skin and in a living skin equivalent (LabSkin™).  |  Iliopoulos, F., et al. 2021. Int J Cosmet Sci. 43: 107-112. PMID: 33238056
  11. The Anti-Ageing and Whitening Potential of a Cosmetic Serum Containing 3-O-ethyl-l-ascorbic Acid.  |  Zerbinati, N., et al. 2021. Life (Basel). 11: PMID: 33946734
  12. Seven cases of allergic contact dermatitis caused by cosmetics containing 3-O-ethyl-L-ascorbic acid.  |  Suzuki, K., et al. 2022. Contact Dermatitis. 86: 421-423. PMID: 34994407
  13. 3-O-Ethyl-L-Ascorbic Acid Doped Enteric-Coated Gelatin Capsules towards the Advanced Oral Curcumin Delivery for Cancers.  |  Lim, DJ. 2022. Polymers (Basel). 14: PMID: 35683880

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

3-O-Ethyl-L-ascorbic acid, 100 mg

sc-266811
100 mg
$61.00