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3-O-Acetyl-β-boswellic acid (CAS 5968-70-7)

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Alternate Names:
A-beta-BA
Application:
3-O-Acetyl-β-boswellic acid is a non-competitive 5-lipoxygenase and topoisomerase I and IIa
CAS Number:
5968-70-7
Purity:
≥95%
Molecular Weight:
498.74
Molecular Formula:
C32H50O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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3-O-Acetyl-β-boswellic acid shows antitumor and anti-inflammatory activities. 3-O-Acetyl-β-boswellic acid is a potent non-redox, non-competitive 5-LO (5-lipoxygenase) and Topo I (topoisomerase I) and Topo II (topoisomerase II) inhibitor leading to apoptosis. 3-O-Acetyl-β-boswellic acid is an inhibitor of Topo II α.


3-O-Acetyl-β-boswellic acid (CAS 5968-70-7) References

  1. Characterization of archaeological frankincense by gas chromatography-mass spectrometry.  |  Mathe, C., et al. 2004. J Chromatogr A. 1023: 277-85. PMID: 14753694
  2. Effects of Boswellia serrata in mouse models of chemically induced colitis.  |  Kiela, PR., et al. 2005. Am J Physiol Gastrointest Liver Physiol. 288: G798-808. PMID: 15539433
  3. Effect of food intake on the bioavailability of boswellic acids from a herbal preparation in healthy volunteers.  |  Sterk, V., et al. 2004. Planta Med. 70: 1155-60. PMID: 15643550
  4. Separation and quantification of terpenoids of Boswellia serrata Roxb. extract by planar chromatography techniques (TLC and AMD).  |  Pozharitskaya, ON., et al. 2006. J Sep Sci. 29: 2245-50. PMID: 17069256
  5. Two new triterpenoids from the resin of Boswellia carterii.  |  Wang, F., et al. 2011. J Asian Nat Prod Res. 13: 193-7. PMID: 21409679
  6. Boswellic acids target the human immune system-modulating antimicrobial peptide LL-37.  |  Henkel, A., et al. 2015. Pharmacol Res. 102: 53-60. PMID: 26361729
  7. Simultaneous quantification of triterpenoic acids by high performance liquid chromatography method in the extracts of gum resin of Boswellia serrata obtained by different extraction techniques.  |  Sharma, N., et al. 2016. Chem Cent J. 10: 49. PMID: 27493682
  8. Transcriptomic Profiling of MDA-MB-231 Cells Exposed to Boswellia Serrata and 3-O-Acetyl-B-Boswellic Acid; ER/UPR Mediated Programmed Cell Death.  |  Mazzio, EA., et al. 2017. Cancer Genomics Proteomics. 14: 409-425. PMID: 29109091
  9. Structure-Activity Relationships of Pentacyclic Triterpenoids as Inhibitors of Cyclooxygenase and Lipoxygenase Enzymes.  |  Vo, NNQ., et al. 2019. J Nat Prod. 82: 3311-3320. PMID: 31774676
  10. Estimation of boswellic acids in herbal formulations containing Boswellia serrata extract and comprehensive characterization of secondary metabolites using UPLC-Q-Tof-MSe.  |  Katragunta, K., et al. 2019. J Pharm Anal. 9: 414-422. PMID: 31890341
  11. Acetyl-α-boswellic acid and Acetyl-β-boswellic acid protects against caerulein-induced pancreatitis via down-regulating MAPKs in mice.  |  Zhang, PY., et al. 2020. Int Immunopharmacol. 86: 106682. PMID: 32563781
  12. Selective anti-cancer activity against melanoma cells using 3-O-acetyl-β-boswellic acid-loaded 3D-Printed scaffold.  |  Jamshidi-Adegani, F., et al. 2022. Nat Prod Res. 1-6. PMID: 36008779
  13. Inhibitory activity of boswellic acids from Boswellia serrata against human leukemia HL-60 cells in culture.  |  Shao, Y., et al. 1998. Planta Med. 64: 328-31. PMID: 9619114

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

3-O-Acetyl-β-boswellic acid, 1 mg

sc-202885
1 mg
$55.00

3-O-Acetyl-β-boswellic acid, 5 mg

sc-202885A
5 mg
$123.00

Hi, can you tell me if this item is fully synthetic? If it is a plant extract, can you disclose the country of origin, or if it is from a country signatory to the Nagoya Protocol? Thanks

Asked by: JeffP
Thank you for your question.3-O-Acetyl-β-boswellic acid is extracted from plant Boswellia serrata. The country of origin is not available.
Answered by: BlakeJ
Date published: 2025-12-08
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Rated 5 out of 5 by from Various publications cite 3Various publications cite 3-O-Acetyl- -boswellic acid as a potent non-redox, non-competitive 5-LO (5-lipoxygenase) and Topo I (topoisomerase I) and Topo II (topoisomerase II) inhibitor. -SCBT Publication Review
Date published: 2015-02-07
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3-O-Acetyl-β-boswellic acid is rated 5.0 out of 5 by 1.
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