3-Nitrobenzenesulfonyl chloride (CAS 121-51-7)
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3-Nitrobenzenesulfonyl chloride is a chemical compound that functions as a sulfonylating agent in organic synthesis. It is used to introduce the sulfonyl group into various organic molecules, particularly in the preparation of sulfonamides and sulfones. The mechanism of action involves the reaction of the chloride group with nucleophilic functional groups, such as amines or alcohols, to form covalent bonds. This allows for the selective modification of specific functional groups within a molecule, enabling the synthesis of complex organic compounds. 3-Nitrobenzenesulfonyl chloride′s reactivity and selectivity make it useful for the modification of organic molecules in development applications. Its mechanism of action involves the formation of stable covalent bonds with specific functional groups, facilitating the synthesis of diverse chemical compounds.
3-Nitrobenzenesulfonyl chloride (CAS 121-51-7) References
- Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4. | Powers, JP., et al. 2006. Bioorg Med Chem Lett. 16: 2842-5. PMID: 16563752
- Synthesis of polymer-bound 4-acetoxy-3-phenylbenzaldehyde derivatives: applications in solid-phase organic synthesis. | Kumar, A., et al. 2006. J Org Chem. 71: 7915-8. PMID: 16995713
- Synthesis and antiviral evaluation of acyclic azanucleosides developed from sulfanilamide as a lead structure. | Gawin, R., et al. 2008. Bioorg Med Chem. 16: 8379-89. PMID: 18778942
- Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors. | Ghosh, AK., et al. 2008. Bioorg Med Chem Lett. 18: 5684-8. PMID: 18796354
- Synthesis and biological evaluation of novel small non-peptidic HIV-1 PIs: the benzothiophene ring as an effective moiety. | Chiummiento, L., et al. 2012. Bioorg Med Chem Lett. 22: 2948-50. PMID: 22414613
- Methyl (R)-2-(2-chloro-phen-yl)-2-(3-nitro-phenyl-sulfon-yloxy)acetate. | Li, YH., et al. 2012. Acta Crystallogr Sect E Struct Rep Online. 68: o1689. PMID: 22719483
- Synthesis of 5-oxyquinoline derivatives for reversal of multidrug resistance. | Dittrich, T., et al. 2012. Beilstein J Org Chem. 8: 1700-4. PMID: 23209502
- Diversity-oriented synthetic strategy for developing a chemical modulator of protein-protein interaction. | Kim, J., et al. 2016. Nat Commun. 7: 13196. PMID: 27774980
- Discovery and Biological Evaluation of a Series of Pyrrolo[2,3-b]pyrazines as Novel FGFR Inhibitors. | Zhang, Y., et al. 2017. Molecules. 22: PMID: 28379191
- Synthesis of novel benzenesulfamide derivatives with inhibitory activity against human cytosolic carbonic anhydrase I and II and Vibrio cholerae α- and β-class enzymes. | Bua, S., et al. 2018. J Enzyme Inhib Med Chem. 33: 1125-1136. PMID: 29987956
- Discovery of Covalent CDK14 Inhibitors with Pan-TAIRE Family Specificity. | Ferguson, FM., et al. 2019. Cell Chem Biol. 26: 804-817.e12. PMID: 30930164
- Indole Chloropyridinyl Ester-Derived SARS-CoV-2 3CLpro Inhibitors: Enzyme Inhibition, Antiviral Efficacy, Structure-Activity Relationship, and X-ray Structural Studies. | Ghosh, AK., et al. 2021. J Med Chem. 64: 14702-14714. PMID: 34528437
- Potent Inhibition of SARS-CoV-2 nsp14 N7-Methyltransferase by Sulfonamide-Based Bisubstrate Analogues. | Ahmed-Belkacem, R., et al. 2022. J Med Chem. 65: 6231-6249. PMID: 35439007
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3-Nitrobenzenesulfonyl chloride, 5 g | sc-238604 | 5 g | $27.00 |