Date published: 2026-4-24

1-800-457-3801

SCBT Portrait Logo
Seach Input

3-Nitro-L-tyrosine (CAS 621-44-3)

0.0(0)
Write a reviewAsk a question

See product citations (3)

Alternate Names:
3-Nitrotyrosine
Application:
3-Nitro-L-tyrosine is an indicator of the formation of peroxynitrite by NO-dependent oxidative damage
CAS Number:
621-44-3
Purity:
98%
Molecular Weight:
226.2
Molecular Formula:
C9H10N2O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

3-Nitro-L-tyrosine, an altered form of tyrosine, an amino acid present in proteins, is generated through the nitration process, wherein nitric oxide reacts with superoxide to modify tyrosine. 3-Nitro-L-tyrosine serves as a significant marker for nitrative stress. Its utility extends to measuring the extent of nitric oxide production in cells, making it a valuable indicator of oxidative stress. Additionally, It has found application in in vitro studies aimed at quantifying the production of nitric oxide within cells. The production of 3-Nitro-L-tyrosine occurs through the nitration of tyrosine, wherein nitric oxide and superoxide react to form peroxynitrite. This peroxynitrite species then participates in the nitration of tyrosine residues present in proteins. 3-Nitro-L-tyrosine, as an essential indicator of oxidative stress, serves as a measurable parameter for evaluating the level of nitric oxide production within cells.


3-Nitro-L-tyrosine (CAS 621-44-3) References

  1. In vivo disposition of 3-nitro-L-tyrosine in rats: implications on tracking systemic peroxynitrite exposure.  |  Tabrizi-Fard, MA., et al. 1999. Drug Metab Dispos. 27: 429-31. PMID: 10232929
  2. Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase.  |  Ischiropoulos, H., et al. 1992. Arch Biochem Biophys. 298: 431-7. PMID: 1416974
  3. Induction of motor neuron apoptosis by free 3-nitro-L-tyrosine.  |  Peluffo, H., et al. 2004. J Neurochem. 89: 602-12. PMID: 15086517
  4. Testosterone induces neuroprotection from oxidative stress. Effects on catalase activity and 3-nitro-L-tyrosine incorporation into alpha-tubulin in a mouse neuroblastoma cell line.  |  Chisu, V., et al. 2006. Arch Ital Biol. 144: 63-73. PMID: 16642786
  5. Developments in the synthesis of a water compatible molecularly imprinted polymer as artificial receptor for detection of 3-nitro-L-tyrosine in neurological diseases.  |  Mergola, L., et al. 2013. Biosens Bioelectron. 40: 336-41. PMID: 22922080
  6. Label-free detection of 3-nitro-l-tyrosine with nickel-doped graphene localized surface plasmon resonance biosensor.  |  Ng, SP., et al. 2017. Biosens Bioelectron. 89: 468-476. PMID: 27085521
  7. Advanced molecular recognition of 3-nitro-L-tyrosine: The use of zwitterion embedded molecularly imprinted mesoporous organosilica with sub-nanomolar sensitivity.  |  Kim, Y. and Lee, J. 2020. Biosens Bioelectron. 160: 112216. PMID: 32339152
  8. Simultaneous LC-MS/MS-Based Quantification of Free 3-Nitro-l-tyrosine, 3-Chloro-l-tyrosine, and 3-Bromo-l-tyrosine in Plasma of Colorectal Cancer Patients during Early Postoperative Period.  |  Fleszar, MG., et al. 2020. Molecules. 25: PMID: 33167555
  9. Peroxynitrite-mediated oxidative protein modifications.  |  Ischiropoulos, H. and al-Mehdi, AB. 1995. FEBS Lett. 364: 279-82. PMID: 7758583
  10. Extensive nitration of protein tyrosines in human atherosclerosis detected by immunohistochemistry.  |  Beckmann, JS., et al. 1994. Biol Chem Hoppe Seyler. 375: 81-8. PMID: 8192861
  11. Detection and quantitation of nitrotyrosine residues in proteins: in vivo marker of peroxynitrite.  |  Crow, JP. and Ischiropoulos, H. 1996. Methods Enzymol. 269: 185-94. PMID: 8791648
  12. Antibodies that recognize nitrotyrosine.  |  Ye, YZ., et al. 1996. Methods Enzymol. 269: 201-9. PMID: 8791650
  13. Identification of 3-nitro-L-tyrosine, a product of nitric oxide and superoxide, as an indicator of oxidative stress in the human brain.  |  Maruyama, W., et al. 1996. J Chromatogr B Biomed Appl. 676: 153-8. PMID: 8852056

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

3-Nitro-L-tyrosine, 1 g

sc-203472
1 g
$33.00

3-Nitro-L-tyrosine, 5 g

sc-203472A
5 g
$82.00