3-(Methylnitrosamino)propionitrile CAS: 60153-49-3
MF: C4H7N3O
MW: 113.12
A carcinogen extracted from betel quid chewer saliva.

3-(Methylnitrosamino)propionitrile (CAS 60153-49-3)

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Synonym: 3-(Methylnitrosoamino)propanenitrile; 3-(N-Nitrosomethylamino)propionitrile
Application: A carcinogen extracted from betel quid chewer saliva
CAS Number: 60153-49-3
Molecular Weight: 113.12
Molecular Formula: C4H7N3O
* Refer to Certificate of Analysis for lot specific data (including water content).

3-(Methylnitrosamino)propionitrile (MNPN) is a potent carcinogen first isolated from the saliva of betel quid chewers. It may also act as a nitric oxide (NO) donor.


References

1. Bartsch, H., et al., . Carcinogen metabolism and DNA adducts in human lung tissues as affected by tobacco smoking or metabolic phenotype: a case-control study on lung cancer patients. Mutation research. 250(1-2): 103-14. PMID: 1944327
2. Su, T., et al., 1996. Expression of CYP2A genes in rodent and human nasal mucosa. Drug metabolism and disposition: the biological fate of chemicals. 24(8): 884-90. PMID: 8869824
3. Guengerich, F P., et al., 2001. Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity. Chemical research in toxicology. 14(6): 611-50. PMID: 11409933

Appearance :
Oil
Physical State :
Liquid
Solubility :
Soluble in chloroform, and ethyl acetate.
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
62163
SMILES :
CN(CCC#N)N=O

Download SDS (MSDS)

Certificate of Analysis

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can I buy small amounts of MNPN and also of MNPA for a project to detect any epigenetic changes to account for the diabetogenic effects seen in betel-chewers, and in the never chewing offspring of male chewers, in both mice and humans?

Asked by: BJB1
Thank you for your inquiry and your interest in this product. The 3-(Methylnitrosamino)propionitrile : sc-391794 is provided in 250 mg units. We do not offer any smaller sizes. This compound is sold as a research grade product for basic scientific research or laboratory use only and is not to be administered to humans or used for medical diagnostics. Please contact our European Support Office in Germany directly for any further questions you may have. You can reach us by phone at: +49 6221 4503 0, by email at: [email protected] or by live chat directly on our website, www.scbt.com We are happy to assist you.
Answered by: Technical Support Europe
Date published: 2017-12-28
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