Molecular structure of 3-(Methylnitrosamino)propionitrile, CAS Number: 60153-49-3
3-(Methylnitrosamino)propionitrile (CAS 60153-49-3)
Alternate Names:
3-(Methylnitrosoamino)propanenitrile; 3-(N-Nitrosomethylamino)propionitrile
Application:
3-(Methylnitrosamino)propionitrile is a carcinogen extracted from betel quid chewer saliva
CAS Number:
60153-49-3
Molecular Weight:
113.12
Molecular Formula:
C4H7N3O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
3-(Methylnitrosamino)propionitrile (MNPN) is a potent carcinogen first isolated from the saliva of betel quid chewers. It may also act as a nitric oxide (NO) donor.
3-(Methylnitrosamino)propionitrile (CAS 60153-49-3) References
- Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity. | Guengerich, FP. 2001. Chem Res Toxicol. 14: 611-50. PMID: 11409933
- A study of betel quid carcinogenesis--VIII. Carcinogenicity of 3-(methylnitrosamino)propionaldehyde in F344 rats. | Nishikawa, A., et al. 1992. Carcinogenesis. 13: 369-72. PMID: 1547526
- A study of betel quid carcinogenesis. IX. Comparative carcinogenicity of 3-(methylnitrosamino)propionitrile and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone upon local application to mouse skin and rat oral mucosa. | Prokopczyk, B., et al. 1991. Cancer Lett. 60: 153-7. PMID: 1933838
- Carcinogen metabolism and DNA adducts in human lung tissues as affected by tobacco smoking or metabolic phenotype: a case-control study on lung cancer patients. | Bartsch, H., et al. 1991. Mutat Res. 250: 103-14. PMID: 1944327
- Cyanoethylation of DNA in vivo by 3-(methylnitrosamino)propionitrile, an Areca-derived carcinogen. | Prokopczyk, B., et al. 1988. Cancer Res. 48: 6780-4. PMID: 3180087
- Synthesis and kinetics of decomposition of 7-(2-cyanoethyl)guanine and O6-(2-cyanoethyl)guanine, markers for reaction of acrylonitrile and 3-(methylnitrosamino)propionitrile with DNA. | Prokopczyk, B., et al. 1988. Carcinogenesis. 9: 2125-8. PMID: 3180348
- A study of betel quid carcinogenesis. 3. 3-(Methylnitrosamino)-propionitrile, a powerful carcinogen in F344 rats. | Wenke, G., et al. 1984. Carcinogenesis. 5: 1137-40. PMID: 6547885
- A study of betel quid carcinogenesis. 1. On the in vitro N-nitrosation of arecoline. | Wenke, G. and Hoffmann, D. 1983. Carcinogenesis. 4: 169-72. PMID: 6825205
- Formation of the acrolein-derived 1,N2-propanodeoxyguanosine adducts in DNA upon reaction with 3-(N-carbethoxy-N-nitrosamino)propionaldehyde. | Chung, FL., et al. 1994. Chem Res Toxicol. 7: 62-7. PMID: 8155826
- Expression of CYP2A genes in rodent and human nasal mucosa. | Su, T., et al. 1996. Drug Metab Dispos. 24: 884-90. PMID: 8869824
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3-(Methylnitrosamino)propionitrile, 250 mg | sc-391794 | 250 mg | $300.00 |