Date published: 2026-4-30

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3-methylindoline (CAS 4375-15-9)

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CAS Number:
4375-15-9
Molecular Weight:
133.19
Molecular Formula:
C9H11N
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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3-Methylindoline is an organic heterocyclic compound, which are known for their nitrogen-containing rings. This compound has a broad range of applications and is highly versatile, possessing several advantageous properties that make it a preferred choice in laboratory experiments. It is also used as a model compound in the study of biological systems, including enzymes and proteins. Moreover, 3-Methylindoline has been employed to examine the mechanism of action of drugs.


3-methylindoline (CAS 4375-15-9) References

  1. Highly enantioselective synthesis of chiral 3-substituted indolines by catalytic asymmetric hydrogenation of indoles.  |  Kuwano, R., et al. 2004. Org Lett. 6: 2213-5. PMID: 15200323
  2. Synthesis of benzannulated N-heterocycles by a palladium-catalyzed C-C/C-N coupling of bromoalkylamines.  |  Thansandote, P., et al. 2007. Org Lett. 9: 5255-8. PMID: 18001046
  3. General approach to the total synthesis of 9-methoxy-substituted indole alkaloids: synthesis of mitragynine, as well as 9-methoxygeissoschizol and 9-methoxy-N(b)-methylgeissoschizol.  |  Ma, J., et al. 2009. J Org Chem. 74: 264-73. PMID: 19046119
  4. Redox isomerization via azomethine ylide intermediates: N-alkyl indoles from indolines and aldehydes.  |  Deb, I., et al. 2011. Org Lett. 13: 812-5. PMID: 21247142
  5. Intramolecular carbonickelation of alkenes.  |  Lhermet, R., et al. 2013. Beilstein J Org Chem. 9: 710-6. PMID: 23766783
  6. Phase-transfer-catalyzed asymmetric synthesis of axially chiral anilides.  |  Liu, K., et al. 2013. Chem Asian J. 8: 3214-21. PMID: 24273122
  7. Formal aromaticity transfer for palladium-catalyzed coupling between phenols and pyrrolidines/indolines.  |  Qiu, Z., et al. 2017. Chem Sci. 8: 6954-6958. PMID: 29147521
  8. Selective Iron Catalyzed Synthesis of N-Alkylated Indolines and Indoles.  |  Wu, J., et al. 2022. Chemistry. 28: e202201809. PMID: 35700072
  9. The pyrolysis of oxindoles at 850°C. II. Oxindoles methylated at N1 and at C3  |  RFC Brown, M Butcher. 1973. Australian Journal of Chemistry. 26(2.) 369 - 374.
  10. Bromo-substituted physostigmine alkaloids from a marine bryozoa Flustra foliacea  |  . 1979,. J. Am. Chem. Soc. 101, 14,: 4012–4013.
  11. Routes toward enantiopure 2-substituted indolines: an overview  |  S Anas, HB Kagan -. October 2009. Tetrahedron: Asymmetry. Volume 20, Issue 19, 6:, Pages 2193-2199.
  12. Recent advances in the synthetic method and mechanism for the important N-heterocyclic compound of 3-methylindole  |  . 24 January 2022. Journal of Heterocyclic Chemistry. Volume59, Issue7: Pages 1135-1143.
  13. Preparation of differentially 1,3-disubstituted indolines by intramolecular carbolithiation  |  WF Bailey, MR Luderer, MJ Mealy. 7 July 2003, Pages 5303-5305. Tetrahedron Letters. Volume 44, Issue 28,: 7 July 2003, Pages 5303-5305.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

3-methylindoline, 1 g

sc-347182
1 g
$435.00

3-methylindoline, 5 g

sc-347182A
5 g
$1203.00