Date published: 2026-7-12

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3-Methylindene-2-carboxylic acid (CAS 34225-81-5)

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CAS Number:
34225-81-5
Molecular Weight:
174.20
Molecular Formula:
C11H10O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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3-Methylindene-2-carboxylic acid (3-MC) is an organic compound belonging to the class of carboxylic acids. It is in the fields of organic synthesis, biochemistry, and physiology. For example, it has been used to study the effects of compounds on the cardiovascular system, as well as investigate the effects of various hormones, such as testosterone and estrogen. 3-Methylindene-2-carboxylic acid modulates the activity of various receptors, such as the GABAa receptor. It acts as an agonist at certain serotonin receptors, which affects mood and behavior.


3-Methylindene-2-carboxylic acid (CAS 34225-81-5) References

  1. Cyclization of arylacetoacetates to indene and dihydronaphthalene derivatives in strong acids. Evidence for involvement of further protonation of O,O-diprotonated beta-ketoester, leading to enhancement of cyclization.  |  Kurouchi, H., et al. 2010. J Am Chem Soc. 132: 807-15. PMID: 20017483
  2. Activity-based near-infrared fluorescent probe for LMP7: a chemical proteomics tool for the immunoproteasome in living cells.  |  Sharma, LK., et al. 2012. Chembiochem. 13: 1899-903. PMID: 22807337
  3. Biodegradation of naphthenic acid surrogates by axenic cultures.  |  Yue, S., et al. 2015. Biodegradation. 26: 313-25. PMID: 26077118
  4. Two-Step Bioorthogonal Activity-Based Protein Profiling of Individual Human Proteasome Catalytic Sites.  |  Xin, BT., et al. 2020. Chembiochem. 21: 248-255. PMID: 31597011
  5. In vitro anticandidal activity and gas chromatography-mass spectrometry (GC-MS) screening of Vitex agnus-castus leaf extracts.  |  Ababutain, IM. and Alghamdi, AI. 2021. PeerJ. 9: e10561. PMID: 33505793
  6. Asymmetric hydrogenation of indene carboxylic acids: stereochemistry of hydrogen addition  |  Borszeky, K., Mallat, T., & Baiker, A. 1999. Tetrahedron: Asymmetry. 10(24): 4781-4789.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

3-Methylindene-2-carboxylic acid, 2.5 g

sc-231863
2.5 g
$153.00