Molecular structure of 3-Methylglutaric acid, CAS Number: 626-51-7
3-Methylglutaric acid (CAS 626-51-7)
CAS Number:
626-51-7
Purity:
≥98%
Molecular Weight:
146.14
Molecular Formula:
C6H10O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
3-Methylglutaric acid (3-MGA) is a naturally occurring organic compound present in various organisms. It plays a vital role as an intermediate in the Krebs cycle, participating in the breakdown of carbohydrates and fatty acids. Additionally, 3-Methylglutaric acid serves as a precursor for the production of essential compounds such as vitamins, hormones, and drugs. Its significance extends to laboratory experiments where it serves as a valuable model compound for studying the structure and function of enzymes and other proteins. Within the Krebs cycle, 3-Methylglutaric acid acts as an intermediary molecule involved in the metabolism of carbohydrates and fatty acids. It serves as a substrate for aconitase, an enzyme responsible for converting citrate into isocitrate.
3-Methylglutaric acid (CAS 626-51-7) References
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- Behr's syndrome and 3-methylglutaconic aciduria. | Sheffer, RN., et al. 1992. Am J Ophthalmol. 114: 494-7. PMID: 1384336
- Biochemical characterization of human 3-methylglutaconyl-CoA hydratase and its role in leucine metabolism. | Mack, M., et al. 2006. FEBS J. 273: 2012-22. PMID: 16640564
- Neurochemical evidence that 3-methylglutaric acid inhibits synaptic Na+,K+-ATPase activity probably through oxidative damage in brain cortex of young rats. | Ribeiro, CA., et al. 2011. Int J Dev Neurosci. 29: 1-7. PMID: 21050883
- Two novel compound heterozygous mutations in OPA3 in two siblings with OPA3-related 3-methylglutaconic aciduria. | Lam, C., et al. 2014. Mol Genet Metab Rep. 1: 114-123. PMID: 24749080
- Experimental Evidence that 3-Methylglutaric Acid Disturbs Mitochondrial Function and Induced Oxidative Stress in Rat Brain Synaptosomes: New Converging Mechanisms. | Colín-González, AL., et al. 2016. Neurochem Res. 41: 2619-2626. PMID: 27278758
- pH Dependence of Liquid-Liquid Phase Separation in Organic Aerosol. | Losey, DJ., et al. 2016. J Phys Chem Lett. 7: 3861-3865. PMID: 27636827
- Monitoring a simple hydrolysis process in an organic solid by observing methyl group rotation. | Beckmann, PA., et al. 2017. Solid State Nucl Magn Reson. 85-86: 1-11. PMID: 28260612
- Selective screening of glutaric acid acidurias by capillary electrophoresis-mass spectrometry. | Fernández-Bravo, J., et al. 2017. J Pharm Biomed Anal. 145: 40-45. PMID: 28648786
- BARTH SYNDROME IN MALE AND FEMALE SIBLINGS CAUSED BY A NOVEL MUTATION IN THE TAZ GENE. | Avdjieva-Tzavella, DM., et al. 2016. Genet Couns. 27: 495-501. PMID: 30226969
- Bezafibrate In Vivo Administration Prevents 3-Methylglutaric Acid-Induced Impairment of Redox Status, Mitochondrial Biogenesis, and Neural Injury in Brain of Developing Rats. | da Rosa-Junior, NT., et al. 2019. Neurotox Res. 35: 809-822. PMID: 30850947
- In vivo evidence that bezafibrate prevents oxidative stress and mitochondrial dysfunction caused by 3-methylglutaric acid in rat liver. | da Rosa-Junior, NT., et al. 2020. Biochimie. 171-172: 187-196. PMID: 32169667
- Incidental Finding of MEGDEL Syndrome Based on Neuroimaging: Case Report. | Alshammari, SA., et al. 2021. Case Rep Neurol. 13: 429-433. PMID: 34326751
- Antioxidant system disturbances and mitochondrial dysfunction induced by 3-methyglutaric acid in rat heart are prevented by bezafibrate. | da Rosa-Junior, NT., et al. 2022. Eur J Pharmacol. 924: 174950. PMID: 35430210
- Inherited 3-methylglutaconic aciduria in two brothers--another defect of leucine metabolism. | Duran, M., et al. 1982. J Pediatr. 101: 551-4. PMID: 6181239
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3-Methylglutaric acid, 5 g | sc-256534 | 5 g | $112.00 |