Molecular structure of 3-Methylcholanthrene, CAS Number: 56-49-5
3-Methylcholanthrene (CAS 56-49-5)
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Alternate Names:
3-Methylcholanthrene is also known as 3-MC.
Application:
3-Methylcholanthrene is a potent aryl hydrocarbon receptor agonist and carcinogen used to induce transformation of cultured cells.
CAS Number:
56-49-5
Molecular Weight:
268.35
Molecular Formula:
C21H16
Supplemental Information:
This is as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
3-Methylcholanthrene is a carcinogen used to induce transformation of cultured cells. It can also be used to induce fibrosarcomas and skin carcinomas in laboratory animals. Furthermore, it can induce the activity of cytochrome P450. 3-Methylcholanthrene is being researched to assess its tumor initiation activity by Bhas 42 cell transformation assay.
3-Methylcholanthrene (CAS 56-49-5) References
- Clonal evolution and progression of 20-methylcholanthrene-induced squamous cell carcinoma of mouse epidermis as revealed by DNA instability and other malignancy markers. | Hirai, K., et al. 2001. Eur J Histochem. 45: 319-32. PMID: 11846000
- A critical role for natural killer T cells in immunosurveillance of methylcholanthrene-induced sarcomas. | Crowe, NY., et al. 2002. J Exp Med. 196: 119-27. PMID: 12093876
- 3-Methylcholanthrene uptake and metabolism in organ culture. | Lasnitzki, I., et al. 1975. Br J Cancer. 32: 219-29. PMID: 1240005
- Effect of 3-methylcholanthrene on the endocrine system and metabolism of the rat and its influence to retard growth of mammary tumors hitherto refractory. | HUGGINS, C. and POLLICE, L. 1958. J Exp Med. 107: 13-32. PMID: 13481252
- 3-methylcholanthrene induces differential recruitment of aryl hydrocarbon receptor to human promoters. | Safe, S. 2010. Toxicol Sci. 117: 1-3. PMID: 20651249
- 3-Methylcholanthrene impacts on the female germ cells of rats without causing systemic toxicity. | Rhon Calderón, EA., et al. 2020. Toxicology. 429: 152328. PMID: 31712135
- 3-Methylcholanthrene alters the hepatic immune response in mice. | Miao, W., et al. 2020. Acta Biochim Biophys Sin (Shanghai). 52: 570-572. PMID: 32293687
- Late effects of cutaneous 3-methylcholanthrene exposure on DNA damage-related pleiotropic growth factors and oxidative stress markers in mice. | Devrim, T., et al. 2020. Bratisl Lek Listy. 121: 325-330. PMID: 32356428
- DNA methylation and hydroxymethylation associated with gene expression regulatory network during 3-methylcholanthrene induced lung cell malignant transformation. | Chen, HQ., et al. 2021. Sci Total Environ. 771: 144839. PMID: 33545462
- Two-stage 3-methylcholanthrene and butylated hydroxytoluene-induced lung carcinogenesis in mice. | Bauer, AK. and Dwyer-Nield, LD. 2021. Methods Cell Biol. 163: 153-173. PMID: 33785163
- Parental exposure 3-methylcholanthrene disturbed the enterohepatic circulation in F1 generation of mice. | Xu, Q., et al. 2022. Chemosphere. 286: 131681. PMID: 34346331
- Parental exposure to 3-methylcholanthrene before gestation adversely affected the endocrine system and spermatogenesis in male F1 offspring. | Xu, Q., et al. 2022. Reprod Toxicol. 110: 161-171. PMID: 35487396
- Inhibitory Effects of 3-Methylcholanthrene Exposure on Porcine Oocyte Maturation. | Zhang, M., et al. 2023. Int J Mol Sci. 24: PMID: 36982641
- The metabolism of 3-methylcholanthrene and some related compounds by rat-liver homogenates. | Sims, P. 1966. Biochem J. 98: 215-28. PMID: 5938646
- 3-Hydroxymethylcholanthrene: metabolic formation from 3-methylcholanthrene and stereoselective metabolism by rat liver microsomes. | Shou, M. and Yang, SK. 1996. Drug Metab Dispos. 24: 595-601. PMID: 8723742
Activator of:
AAT, AKR1C12, AKR1E1, AKR7A2, ALKB, ARH1, Arnt 1, Cdc23, CHPPR, CYP1A2, CYP2A22, CYP2A6, CYP2B13, CYP2B19, Cyp2c65, CYP2F2, CYP4A32, CYP4F11, CYP4F2, DDX49, EG226601, EG226604, EPHX2, Gm1862, MRP2, PCB, SULT2B1, TMEM68, UBE2D4, UGT2B10, UGT2B15, UGT2B17, and UGT2B37.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3-Methylcholanthrene, 100 mg | sc-252030 | 100 mg | $388.00 | |||
3-Methylcholanthrene, 250 mg | sc-252030A | 250 mg | $831.00 |